Project description:The GumB protein is an IgaA-family member that negatively regulates the Rcs stress response system in the bacterium Serratia marcescens. Mutation of the gumB gene results in increased RCs system activity of numerous genes including those involved in flagellar based motility and capsular polysaccharide formation.
Project description:A genome-scale metabolic model for the gram-positive, and polysaccharide degrading bacterium Ruminiclostridium cellulolyticum H10. The model includes manually reconstructed pathways for degradation of oligosaccharides from cellulose, xyloglucan, and arabinoxylan. The model has been compared and curated to experimental data. The draft model was initially created using CarveMe (version 1.5.1) with the gram-positive universal model as the template.
Project description:Typhoid fever is caused by the Gram-negative bacterium Salmonella enterica serovar Typhi. Bulk RNA-sequencing (RNA-seq) data were generated from blood samples obtained from adult human volunteers enrolled in a vaccine trial involving two vaccines against typhoid fever, a plain polysaccharide vaccine, ViPS and a glycoconjugate vaccine, ViTCV. The participants were then challenged with S. Typhi in a controlled human infection model (CHIM).