Project description:Here we report the transcriptional response to SARS-CoV-2 in Syrian golden hamsters and compare it to the host response against Influenza A virus. The virus replicates fast to high titers in the respiratory tract followed by a local and systemic inflammatory response. A roust IFN-I reponse is mounted and lasts at leaset fourteen days in distal tissues together with other lasting transcriptional changes.
