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Mus musculus

ABSTRACT: Gene expression profiling of sciatic nerves from Zeb2cKO and control mice

PROVIDER: PRJNA300202 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR2827534.fastq.gz	Fastqsanger.gz
	SRR2827535.fastq.gz	Fastqsanger.gz
	SRR2827536.fastq.gz	Fastqsanger.gz
	SRR2827537.fastq.gz	Fastqsanger.gz

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Project description:We performed gene expression pofiling of Zeb2cKO and control sciatic nerves and identified significantly changed genes ZEB2 is also known as SIP1 4 RNA-Seq samples from P7 sciatic nerves of Ctrl and Zeb2 cKO mice (duplicatess, Ctrl and cKO)

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Genome-wide analysis of Schwann cell gene expression in LKB1-SCKO mutant mice prior to occurrence of axon degeneration

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Project description:The transcriptome of sciatic nerves was investigated by RNA sequencing. We compared the transcriptome of ZH3 sciatic nerves to WT sciatic nerves in two age groups. Differentially expressed genes were considered as indicators of peripheral nerve damage in ZH3 mice. Then, we compared the sciatic nerve transcriptome of ZH3 mice chronically treated with a dimeric PrP-fusion protein (FT2Fc) to the two control groups treated with either buffer or mouse IgG. This comparison revealed specific changes induced by FT2Fc treatment. Contrary to our hypothesis, FT2Fc treatment did not alter the expression of the genes that were dysregulated in young and old ZH3 mice (as identified in the first part of the study).

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