Project description:SUB1 is known to be playing critical role in vital cellular processes such as DNA replication, repair and heterochromatization. Expression profiling studies in several cancers show its overexpression. However, its regulation and function in cancer has been less explored. Our study has indicated high expression of SUB1 in aggressive prostate cancer, we also found that the knockdown of SUB1 led to alterations in cell proliferation, invasion and migration. In addition, we found that mir-101, a tumor suppressor microRNA targets and regulates the expression of SUB1
Project description:Asthma is a chronic inflammatory airway disease characterized by airway inflammation and remodeling. The role of 15-oxo-5Z,8Z,11Z,13E-eicosatetraenoic acid (15-oxoETE), a 15-HETE metabolite catalyzed by 15-prostaglandin dehydrogenase (15-PGDH), has been relatively unexplored in asthma. In this study, we used RNA-seq to explore the effect of 15-KETE on the transcriptome of airway epithelial cells, aiming to identify its potential downstream targets and mechanisms of action.
