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Seven fish species (three sharks, one ray, and three teleost fish)

ABSTRACT: RNA-seq of heart tissue from 7 fish species, including four elasmobranchs (white shark, shortfin mako, great hammerhead, and yellow stingray) and three teleost species (swordfish, hogfish, and ocean surgeonfish) Raw sequence reads

PROVIDER: PRJNA313962 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3213610_1.fastq.gz	Fastqsanger.gz
	SRR3213610_2.fastq.gz	Fastqsanger.gz
	SRR3213611_1.fastq.gz	Fastqsanger.gz
	SRR3213611_2.fastq.gz	Fastqsanger.gz
	SRR3213612_1.fastq.gz	Fastqsanger.gz

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Project description:The dentition of elasmobranchs (sharks, skates and rays) is uniquely productive, capable of both rapid and continuous, lifelong regeneration. Elasmobranchs represent an important group of vertebrates with a deep evolutionary history, possessing several ancient and basal characters, i.e., the continuously regenerative dentition from a specialized dental lamina. The dental lamina is an expanded component of the oral epithelia that is responsible for initiating and producing new teeth among all toothed-vertebrates. In sharks, this dynamic epithelial unit is permanent and continuous – meaning it extends to cover the entirety of each jaw (jaw-wide) and develops early during embryogenesis and retained to produce teeth for the life of the shark. It is rare for a truly embryonic vertebrate tissue to be retained for its original function for the life of the organism. The dental lamina in sharks is unique and houses teeth in a developmental series from the deepest part, where teeth are initiated, through stages of tooth development in the form of a related, family of teeth to eruption and functionality of the advanced teeth at the jaw margin. How teeth are made and regenerated is an important question in vertebrate biology; here we investigated this question in the small spotted catshark (Scyliorhinus canicula), a new model in the field of developmental biology. Specifically, we divided the shark dental lamina into stage-compartments as follows: (i) the initiation site – the successional lamina (SL); (ii) the early developing teeth (ET); (iii) the late stage developing teeth (LT); (iv) the tooth-taste junction between the superficial oral and dental epithelium at the jaw margin that separates the taste territory and the dental lamina proper (TTJ); and basi-hyal oral epithelium that is strictly non-dental and only contains taste buds (BHTB). These 5 compartments each house both a shared and unique signature of gene transcripts. This study aims to understand the transcriptomic basis of continuous tooth regeneration in the shark. In this study we combine X-ray computed tomography, classic histology, insitu hybridization, immunohistochemistry, and functional assays of novel markers, and de novo and genome guided transcriptome assemblies for each of these 5 dental lamina compartments of the hatchling (stage 34) catshark (S. canicula).

Dataset Information

Seven fish species (three sharks, one ray, and three teleost fish)

Dataset's files

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