Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mouse gut metagenome isolate:gut mucus

ABSTRACT: mouse gut metagenome isolate:gut mucus Metagenome

PROVIDER: PRJNA315932 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

anaerobic digester metagenome isolate:Skin-mucus and Gut

Project description:anaerobic digester metagenome isolate:Skin-mucus and Gut Metagenome

| PRJNA594800 | ENA

mouse gut metagenome isolate:Mouse feces

Project description:mouse gut metagenome isolate:Mouse feces Genome sequencing

| PRJNA533950 | ENA

Goblet cell-expressed microprotein FXYD3 determines gut homeostasis by maintaining mucus barrier integrity

Project description:The intestinal mucus layer produced by goblet cells is a critical component of innate immunity. The key host factors and regulatory mechanisms controlling goblet cell function in mucus layer formation remain poorly understood. This study identifies a function for the microprotein FXYD domain-containing transport regulator 3 (FXYD3) in goblet cells in regulating mucus layer formation to maintain intestinal homeostasis. Deficiency of FXYD3 in mouse intestinal epithelial cellsresults in a damaged mucus barrier, leading to microbiota dysbiosis and increased susceptibility to colitis. Mechanistically, FXYD3 interacts with endoplasmic reticulum Ca2+-ATPase SERCA2 to enhances its pump activity. FXYD3 deficiency causes defects in ER Ca2+ homeostasis and mucin glycosylation, impairing mucus layer integrity. Furthermore, metabolites of gut microbiota, propionate and butyrate promoteFXYD3 expression. In ulcerative colitis (UC) patients, FXYD3 expression is significantly downregulated and correlats with disease severity. These findings indicat FXYD3 is a key mediator of host-microbiota interactions for intestinal health.

2025-09-25 | GSE309210 | GEO

mouse gut metagenome isolate:china

Project description:mouse gut metagenome isolate:china Raw sequence reads

| PRJNA1311731 | ENA

mouse gut metagenome isolate:OTU60

Project description:mouse gut metagenome isolate:OTU60 Genome sequencing and assembly

| PRJNA898979 | ENA

gill mucus metagenome

Project description:gill mucus metagenome Metagenome

| PRJNA545696 | ENA

The gut microbiota affects the mucus barrier

Project description:Two C57BL/6 mice colonies maintained in two rooms in the same specific pathogen free (SPF) facility were found to have different gut microbiota and a mucus phenotype specific for each colony. The thickness and growth of the colon mucus was similar in the two colonies, but one colony had mucus not penetrable to bacteria or bacterial-sized beads, similar to what occurs in free-living wild mice. On the other hand, the other colony had an inner mucus layer that was penetrable to bacteria and beads. These different properties of the mucus in the two rooms were dependent on the microbiota, as the phenotypes were transmissible by transfer of ceacal microbiota to germ-free mice. Mice with an impenetrable mucus layer had increased amounts of Erysipelotrichi, while mice with a penetrable mucus layer had higher levels of Proteobacteria and TM7 bacteria in the distal colon mucus. Thus bacteria affect mucus barrier properties in ways that can have implications for health and disease.

2015-02-09 | PXD001479 | Pride

mouse gut metagenome

Project description:mouse gut metagenome Metagenome

| PRJNA557297 | ENA

mouse gut metagenome

Project description:mouse gut metagenome Metagenome

| PRJNA560119 | ENA

mouse gut metagenome

Project description:mouse gut metagenome Metagenome

| PRJNA732726 | ENA