Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Danio rerio

ABSTRACT: FOXN3 regulates hepatic glucose utilization

PROVIDER: PRJNA317597 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR3342390.fastq.gz	Fastqsanger.gz
	SRR3342391.fastq.gz	Fastqsanger.gz
	SRR3342392.fastq.gz	Fastqsanger.gz
	SRR3342393.fastq.gz	Fastqsanger.gz
	SRR3342388.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Danio rerio

Project description:Transcriptome of high glucose treated zebrafish embryos

| PRJNA1064282 | ENA

Danio rerio

Project description:Baseline hepatic mRNA expression in three zebrafish strains

| PRJNA392172 | ENA

Danio rerio

Project description:Differentially expressed genes associated with hepatic steatosis in zebrafish

| PRJNA211818 | ENA

Danio rerio

Project description:Danio rerio HLX regulates hematopoiesis

| PRJNA389809 | ENA

High Throughput Danio Rerio Energy Expenditure Assay.

Project description:Zebrafish are an important model organism with inherent advantages that have the potential to make zebrafish a widely applied model for the study of energy homeostasis and obesity. The small size of zebrafish allows for assays on embryos to be conducted in a 96- or 384-well plate format, Morpholino and CRISPR based technologies promote ease of genetic manipulation, and drug treatment by bath application is viable. Moreover, zebrafish are ideal for forward genetic screens allowing for novel gene discovery. Given the relative novelty of zebrafish as a model for obesity, it is necessary to develop tools that fully exploit these benefits. Herein, we describe a method to measure energy expenditure in thousands of embryonic zebrafish simultaneously. We have developed a whole animal microplate platform in which we use 96-well plates to isolate individual fish and we assess cumulative NADH2 production using the commercially available cell culture viability reagent alamarBlue. In poikilotherms the relationship between NADH2 production and energy expenditure is tightly linked. This energy expenditure assay creates the potential to rapidly screen pharmacological or genetic manipulations that directly alter energy expenditure or alter the response to an applied drug (e.g. insulin sensitizers).

| S-EPMC4781700 | biostudies-other

Danio rerio

Project description:Hepatic transcriptional responses of zebrafish to chronic, low dose pharmaceutical exposures

| PRJNA186569 | ENA

Danio rerio

Project description:Effect of waterborne exposure to carcinogenic PAHs on adult zebrafish hepatic transcriptome

| PRJNA187042 | ENA

Danio rerio

Project description:Sexual dimorphism in the zebrafish hepatic transcriptome and response to dietary carbohydrate

| PRJNA102211 | ENA

Danio rerio

Project description:Glucose Metabolism impacts the spatio-temporal onset and magnitude of HSC induction in vivo