Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mouse gut metagenome

ABSTRACT: Mus musculus intestinal transcriptome and microbiome in diet-induced obesity

PROVIDER: PRJNA320922 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR3490420.fastq.gz	Fastqsanger.gz
	SRR3490421.fastq.gz	Fastqsanger.gz
	SRR3490402.fastq.gz	Fastqsanger.gz
	SRR3490412.fastq.gz	Fastqsanger.gz
	SRR3490422.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 186

Similar Datasets

mouse gut metagenome

Project description:Mus musculus intestinal transcriptome and microbiome in diet-induced obesity

| PRJNA551783 | ENA

Profiling mouse exosomal RNA to understand antibiotics treatment consequences

Project description:We isolated circulating extracellular vesicles (EVs) from plasma collected from adolescent mus musculus. RNA sequencing revealed that mouse plasma EVs contain RNA aligned to the microbiome.

2025-07-24 | GSE302894 | GEO

Directed Remodeling of the Mouse Gut Microbiome Inhibits the Development of Atherosclerosis [mouse tissue]

Project description:The gut microbiome is a malleable microbial community that can remodel in response to various factors, including diet, and contribute to the development of several chronic diseases, including atherosclerosis. We devised an in vitro screening protocol of the mouse gut microbiome to discover molecules that can selectively modify bacterial growth. This approach was used to identify cyclic D,L-α-peptides that remodeled the Western diet (WD) gut microbiome toward the low-fat-diet microbiome state. Daily oral administration of the peptides in WD-fed LDLr-/- mice reduced plasma total cholesterol levels and atherosclerotic plaques. Depletion of the microbiome with antibiotics abrogated these effects. Peptide treatment reprogrammed the microbiome transcriptome, suppressed the production of pro-inflammatory cytokines (including interleukin-6, tumor necrosis factor-α and interleukin-1β), rebalanced levels of short-chain fatty acids and bile acids, improved gut barrier integrity and increased intestinal T regulatory cells. Directed chemical manipulation provides an additional tool for deciphering the chemical biology of the gut microbiome and might advance microbiome-targeted therapeutics.

2019-12-31 | GSE104914 | GEO

Directed Remodeling of the Mouse Gut Microbiome Inhibits the Development of Atherosclerosis [bacteria]

2019-12-31 | GSE104913 | GEO

A probiotics strain attenuating the effects of aspirin in the gut

Project description:Transcriptome analysis of partially degraded and fragmented RNA samples from mus musculus gut Global gene expression profiling has shown the gut transcripts changes through administration of aspirin while probiotics strain administration beforehand attenuates the effect more than teprenone.

2014-01-07 | GSE53851 | GEO

Metabolomic data ALMS1 WT and ALMS1 KO mice treated or not with a preventive approach of anti-ACBP antibody

Project description:Raw metabolomic data from Mus musculus liver used in the "Identification of ACBP as a potential target in ciliopathic obesity using multi-omic network analysis." The dataset includes files from ALMS1 WT and ALMS1 KO mice treated or not with a preventive approach of anti-ACBP antibodies and mice obese by fatty diet as obesity control independent of Alstrom syndrome.

2025-10-06 | MSV000099393 | MassIVE

Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse

Project description:Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, is one of the world’s longest selection experiments for high body mass and was previously described as a model for metabolic healthy (benign) obesity. The present study further characterizes the geno- and phenotypes of this non-inbred mouse line and testes its suitability as an interventional obesity model. In contrast to previous findings, our data suggest that Titan mice are metabolically unhealthy obese and short-lived. Line-specific patterns of genetic invariability are in accordance with observed phenotypic traits. Titan mice also show modifications in the liver transcriptome, proteome, and epigenome linked to metabolic (dys)regulations. Importantly, dietary intervention partially reversed the metabolic phenotype in Titan mice and significantly extended their life expectancy. Therefore, the Titan mouse line is a valuable resource for translational and interventional obesity research

2022-05-04 | PXD019030 | Pride

mouse gut metagenome

Project description:FK506 binding protein 5 deficiency regulates gut microbiome against diet-induced obesity in mice

| PRJNA610239 | ENA

gut metagenome

Project description:QQ Diet-Induced Obesity

| PRJNA918340 | ENA

mouse gut metagenome

Project description:Interaction of gut microbiota and anti-obesity drugs in diet induced obesity model

| PRJDB12833 | ENA