Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Danio rerio

ABSTRACT: Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88

PROVIDER: PRJNA324288 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR3622450.fastq.gz	Fastqsanger.gz
	SRR3622451.fastq.gz	Fastqsanger.gz
	SRR3622442.fastq.gz	Fastqsanger.gz
	SRR3622452.fastq.gz	Fastqsanger.gz
	SRR3622443.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88

Project description:Host pathways mediating changes in immune states elicited by intestinal microbial colonization are incompletely characterized. Here we describe alterations of the host immune state induced by colonization of germ-free zebrafish larvae with an intestinal microbial community or single bacterial species. We show that microbiota-induced changes in intestinal leukocyte subsets and whole-body host gene expression are dependent on the innate immune adaptor gene myd88. Similar patterns of gene expression are elicited by colonization with conventional microbiome, as well as mono-colonization with two different zebrafish commensal bacterial strains. By studying loss-of-function myd88 mutants, we find that colonization suppresses Myd88 at the mRNA level. Tlr2 is essential for microbiota-induced effects on myd88 transcription and intestinal immune cell composition.

2018-10-05 | GSE82200 | GEO

Danio rerio

Project description:Pathogen recognition and activation of the innate immune response in zebrafish: MyD88 mutants

| PRJNA170449 | ENA

Danio rerio

Project description:Traf6 function in the innate immune response of zebrafish embryos

| PRJNA125775 | ENA

Danio rerio

Project description:Traf6 function in the innate immune response of zebrafish embryos

| PRJNA125355 | ENA

Danio rerio

Project description:Pathogen recognition and activation of the innate immune response in zebrafish

| PRJNA152357 | ENA

Danio rerio

Project description:Deep sequencing of the innate immune transcriptomic response of zebrafish embryos to Salmonella infection

| PRJNA128589 | ENA

Danio rerio

Project description:Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells [zebrafish]

| PRJNA374872 | ENA

Danio rerio

Project description:Activation of innate immune pathways after brain injury promotes scar formation and impairs tissue recovery

| PRJNA384318 | ENA

Danio rerio

Project description:MicroRNA-146 function in the innate immune response of zebrafish embryos to Salmonella typhimurium infection [RNA-seq]

| PRJNA193208 | ENA

Danio rerio

Project description:MicroRNA-146 function in the innate immune response of zebrafish embryos to Salmonella typhimurium infection [miRNA profile]

| PRJNA194604 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data