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Evolution of a transcriptional regulator from a transmembrane nucleoporin

ABSTRACT: Evolution of a transcriptional regulator from a transmembrane nucleoporin

PROVIDER: PRJNA326730 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3707264.fastq.gz	Fastqsanger.gz
	SRR3707265.fastq.gz	Fastqsanger.gz
	SRR3707266.fastq.gz	Fastqsanger.gz
	SRR3707267.fastq.gz	Fastqsanger.gz
	SRR3707268.fastq.gz	Fastqsanger.gz

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Evolution of a transcriptional regulator from a transmembrane nucleoporin.

Project description:Nuclear pore complexes (NPCs) emerged as nuclear transport channels in eukaryotic cells ∼1.5 billion years ago. While the primary role of NPCs is to regulate nucleo-cytoplasmic transport, recent research suggests that certain NPC proteins have additionally acquired the role of affecting gene expression at the nuclear periphery and in the nucleoplasm in metazoans. Here we identify a widely expressed variant of the transmembrane nucleoporin (Nup) Pom121 (named sPom121, for "soluble Pom121") that arose by genomic rearrangement before the divergence of hominoids. sPom121 lacks the nuclear membrane-anchoring domain and thus does not localize to the NPC. Instead, sPom121 colocalizes and interacts with nucleoplasmic Nup98, a previously identified transcriptional regulator, at gene promoters to control transcription of its target genes in human cells. Interestingly, sPom121 transcripts appear independently in several mammalian species, suggesting convergent innovation of Nup-mediated transcription regulation during mammalian evolution. Our findings implicate alternate transcription initiation as a mechanism to increase the functional diversity of NPC components.

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Evolution of a transcriptional regulator from a transmembrane nucleoporin

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Evolution of a transcriptional regulator from a transmembrane nucleoporin

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