Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA327889 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Integrative omics analysis in HCC samples [lncRNA expression]
| PRJNA327890 | ENA
Project description:Integrative omics analysis in HCC samples
| PRJNA327799 | ENA
Project description:RNA extracted at 240min. Samples are rRNA depleted. Expression measurement of Homo sapiens genes.
2019-07-31 | GSE114179 | GEO
Project description:RMA expression data for liver samples from subjects with HCV cirrhosis with and without concomitant HCC
2025-01-24 | E-GEOD-17967 | ExpressionAtlas
Project description:Gene expression analysis of lung cancer samples and healthy controls
2025-01-23 | E-MTAB-5231 | ExpressionAtlas
Project description:Integrative analysis of histone ChIP-seq and gene expression microarray data using Bayesian mixture models
2015-07-27 | E-GEOD-49975 | ExpressionAtlas
Project description:Integrative genomic analysis in HCC samples
| PRJNA430680 | ENA
Project description:GENE EXPRESSION ANALYSIS OF SYNOVIAL BIOPSIES AND PERIPHERAL BLOOD SAMPLES FROM PSORIATIC ARTHRITIS
2025-01-23 | E-MTAB-3201 | ExpressionAtlas
Project description:An integrative analysis of skeletal muscle insulin resistance
2025-01-23 | E-MTAB-3420 | ExpressionAtlas
Project description:We have sequenced miRNA libraries from human embryonic, neural and foetal mesenchymal stem cells. We report that the majority of miRNA genes encode mature isomers that vary in size by one or more bases at the 3’ and/or 5’ end of the miRNA. Northern blotting for individual miRNAs showed that the proportions of isomiRs expressed by a single miRNA gene often differ between cell and tissue types. IsomiRs were readily co-immunoprecipitated with Argonaute proteins in vivo and were active in luciferase assays, indicating that they are functional. Bioinformatics analysis predicts substantial differences in targeting between miRNAs with minor 5’ differences and in support of this we report that a 5’ isomiR-9-1 gained the ability to inhibit the expression of DNMT3B and NCAM2 but lost the ability to inhibit CDH1 in vitro. This result was confirmed by the use of isomiR-specific sponges. Our analysis of the miRGator database indicates that a small percentage of human miRNA genes express isomiRs as the dominant transcript in certain cell types and analysis of miRBase shows that 5’ isomiRs have replaced canonical miRNAs many times during evolution. This strongly indicates that isomiRs are of functional importance and have contributed to the evolution of miRNA genes
2014-08-06 | GSE58734 | GEO