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Streptomyces lincolnensis

ABSTRACT: Streptomyces lincolnensis overview

PROVIDER: PRJNA336074 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR27589946_1.fastq.gz	Fastqsanger.gz
	SRR27589946_2.fastq.gz	Fastqsanger.gz
	SRR27589947_1.fastq.gz	Fastqsanger.gz
	SRR27589947_2.fastq.gz	Fastqsanger.gz

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Streptomyces lincolnensis

Project description:Streptomyces lincolnensis Raw sequence reads

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Streptomyces lincolnensis

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Streptomyces lincolnensis strain:B48

Project description:Streptomyces lincolnensis strain:B48 Genome sequencing

| PRJNA588965 | ENA

Streptomyces lincolnensis strain:L4

Project description:Streptomyces lincolnensis strain:L4 Genome sequencing and assembly

| PRJNA753994 | ENA

Streptomyces lincolnensis strain:NRRL2936

Project description:Streptomyces lincolnensis strain:NRRL2936 Genome sequencing and assembly

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The genome of Streptomyces rimosus shows a novel structure compared to other Streptomyces

Project description:This study compared the genome of Streptomyces rimosus rimosus against that of Streptomyces coelicolor. It also compared 4 strains with changes in oxytetracycline production and derived from G7, the type strain, against G7. Keywords: Comparative genomic hybridization

2008-01-11 | GSE10126 | GEO

Project description:Streptomyces lincolnensis Transcriptome

| PRJNA923164 | ENA

Genome-wide binding site profiling of NdgR in Streptomyces coelicolor

Project description:We identified genome-wide binding regions of NdgR in Streptomyces coelicolor using chromatin immunoprecipitation sequencing (ChIP-seq). We constructed 6×myc-tagged NdgR strain using homologous recombination with myc-tagging vector. Analysis of the sequencing data aligned to Streptomyces coelicolor genome database (NC_003888).

2014-12-29 | GSE59010 | GEO

Ribosome profiling of Streptomyces griseus NBRC13350 and Streptomyces venezuelae ATCC15439

Project description:We performed ribosome profiling which is the deep-sequencing of mRNA fragments protected by translating ribosome for two Streptomyces species through different growth phases to provide the translatome data

2020-03-03 | GSE138278 | GEO

Three new LmbU targets outside lmb cluster inhibit lincomycin biosynthesis in Streptomyces lincolnensis.

Project description:BackgroundAntibiotics biosynthesis is usually regulated by the cluster-situated regulatory gene(s) (CSRG(s)), which directly regulate the genes within the corresponding biosynthetic gene cluster (BGC). Previously, we have demonstrated that LmbU functions as a cluster-situated regulator (CSR) of lincomycin. And it has been found that LmbU regulates twenty non-lmb genes through comparative transcriptomic analysis. However, the regulatory mode of CSRs' targets outside the BGC remains unknown.ResultsWe screened the targets of LmbU in the whole genome of Streptomyces lincolnensis and found fourteen candidate targets, among which, eight targets can bind to LmbU by electrophoretic mobility shift assays (EMSA). Reporter assays in vivo revealed that LmbU repressed the transcription of SLINC_0469 and SLINC_1037 while activating the transcription of SLINC_8097. In addition, disruptions of SLINC_0469, SLINC_1037, and SLINC_8097 promoted the production of lincomycin, and qRT-PCR showed that SLINC_0469, SLINC_1037, and SLINC_8097 inhibited transcription of the lmb genes, indicating that all the three regulators can negatively regulate lincomycin biosynthesis.ConclusionsLmbU can directly regulate genes outside the lmb cluster, and these genes can affect both lincomycin biosynthesis and the transcription of lmb genes. Our results first erected the cascade regulatory circuit of LmbU and regulators outside lmb cluster, which provides the theoretical basis for the functional research of LmbU family proteins.

| S-EPMC10763038 | biostudies-literature

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