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Homo sapiens

ABSTRACT: BRCA1/RNApII regulation in Ewing's sarcoma (ChIP-seq)

PROVIDER: PRJNA344334 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR4293210.fastq.gz	Fastqsanger.gz
	SRR4293220.fastq.gz	Fastqsanger.gz
	SRR4293211.fastq.gz	Fastqsanger.gz
	SRR4293221.fastq.gz	Fastqsanger.gz
	SRR4293212.fastq.gz	Fastqsanger.gz

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Molecular mechanism of EPC1-PHF1 fusion protein (ChIP-seq Homo Sapiens)

Project description:In this study, we characterize the fusion protein produced by the EPC1-PHF1 translocation in Low Grade Endometrial Stromal Sarcoma (LG-ESS) and Ossifying FibroMyxoid Tumors (OFMT). We express the fusion protein and necessary controls in K562 Cells. The fusion protein assembles a mega-complex harboring both NuA4/TIP60 and PRC2 subunits and enzymatic activities and leads to mislocalization of chromatin marks in the genome, linked to aberrant gene expression.

2020-11-25 | GSE162118 | GEO

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