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Homo sapiens

ABSTRACT: RNA-seq of human adipose tissue following n-3 PUFA supplementation and evoked endotoxemia

PROVIDER: PRJNA344735 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR4300100_1.fastq.gz	Fastqsanger.gz
	SRR4300100_2.fastq.gz	Fastqsanger.gz
	SRR4300110_1.fastq.gz	Fastqsanger.gz
	SRR4300110_2.fastq.gz	Fastqsanger.gz
	SRR4300120_1.fastq.gz	Fastqsanger.gz

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RNA-seq of human adipose tissue following n-3 PUFA supplementation and evoked endotoxemia

Project description:Dietary consumption of long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) may protect against cardiometabolic disease through modulation of systemic and adipose inflammation. However, it is often difficult to detect the subtle effects of n-3 PUFA on inflammatory biomarkers in traditional intervention studies. We aimed to identify novel n-3 PUFA modulated gene expression using unbiased adipose transcriptomics during evoked endotoxemia in a clinical trial of n-3 PUFA supplementation. We analyzed adipose gene expression using RNA sequencing in the fenofibrate and omega-3 fatty acid modulation of endotoxemia (FFAME) trial of healthy individuals at three timepoints: before and after n-3 PUFA supplementation (n=8; 3600mg/day EPA/DHA) for 6weeks compared with placebo (n=6), as well as during a subsequent evoked inflammatory challenge (lipopolysaccharide 0.6ng/kg i.v.). As expected, supplementation with n-3 PUFA vs. placebo alone had only modest effects on adipose tissue gene expression. In contrast, the transcriptomic response to evoked endotoxemia was significantly modified by n-3 PUFA supplementation, with several genes demonstrating significant n-3 PUFA gene-nutrient interactions. These data highlight potential mechanisms whereby n-3 PUFA consumption may enhance the immune response to an inflammatory challenge.

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