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Pervasive concerted evolution in gene expression shapes cell type transcriptomes

ABSTRACT: Pervasive concerted evolution in gene expression shapes cell type transcriptomes

PROVIDER: PRJNA349994 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR4437370.fastq.gz	Fastqsanger.gz
	SRR4437361.fastq.gz	Fastqsanger.gz
	SRR4437371.fastq.gz	Fastqsanger.gz
	SRR4437362.fastq.gz	Fastqsanger.gz
	SRR4437372.fastq.gz	Fastqsanger.gz

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Pervasive concerted evolution in gene expression shapes cell type transcriptomes

Project description:Complex multicellular organisms have evolved numerous cell types with many different functions. Comparative transcriptomic data yields valuable insights into cell type, tissue, and organ evolution. However, interpreting this data requires understanding how transcriptomes evolve. A particularly difficult problem is that cell type transcriptomes may not evolve independently, a key assumption of most evolutionary analyses. Non-independence of cell types can occur when cell types share regulatory mechanisms. This leads to concerted evolution in gene expression across different cell types, confounding efforts to unravel the history of cell type evolution, and identify cell type-specific patterns of expression. Here we present a statistical model to estimate the level of concerted transcriptome evolution and apply it to published and new data. The results indicate that tissues undergo pervasive concerted evolution in gene expression. Tissues related by morphology or developmental lineage exhibit higher levels of concerted evolution. Concerted evolution also causes tissues from the same species to be more similar in gene expression to each other than to homologous tissues in another species. This result may explain why some tissue transcriptomes cluster by species rather than homology. Our analysis of bird skin appendages data suggests levels of concerted evolution also varies with phylogenetic age of the tissue. Our study illustrates the importance of accounting for concerted evolution when interpreting comparative transcriptome data, and should serve as a foundation for future investigations of cell type evolution.

2017-10-13 | GSE89040 | GEO

Project description:The evolution and diversification of cell types is a key means by which animal complexity evolves. Recently, hierarchical clustering and phylogenetic methods have been applied to RNA-seq data to infer cell type evolutionary history and homology. A major challenge for interpreting this data is that cell type transcriptomes may not evolve independently due to correlated changes in gene expression. This nonindependence can arise for several reasons, such as common regulatory sequences for genes expressed in multiple tissues, that is, pleiotropic effects of mutations. We develop a model to estimate the level of correlated transcriptome evolution (LCE) and apply it to different data sets. The results reveal pervasive correlated transcriptome evolution among different cell and tissue types. In general, tissues related by morphology or developmental lineage exhibit higher LCE than more distantly related tissues. Analyzing new data collected from bird skin appendages suggests that LCE decreases with the phylogenetic age of tissues compared, with recently evolved tissues exhibiting the highest LCE. Furthermore, we show correlated evolution can alter patterns of hierarchical clustering, causing different tissue types from the same species to cluster together. To identify genes that most strongly contribute to the correlated evolution signal, we performed a gene-wise estimation of LCE on a data set with ten species. Removing genes with high LCE allows for accurate reconstruction of evolutionary relationships among tissue types. Our study provides a statistical method to measure and account for correlated gene expression evolution when interpreting comparative transcriptome data.

| S-EPMC5800078 | biostudies-literature

Heterochronic Evolution Reveals Modular Timing Changes in Budding Yeast Transcriptomes

Project description:This SuperSeries is composed of the following subset Series: GSE24770: Heterochronic Evolution Reveals Modular Timing Changes in Budding Yeast Transcriptomes (Mutation Accumulation Lines) GSE24771: Heterochronic Evolution Reveals Modular Timing Changes in Budding Yeast Transcriptomes (Natural Strain Timecourse) Refer to individual Series

2010-10-19 | E-GEOD-24772 | biostudies-arrayexpress

Pervasive lesion segregation shapes cancer genome evolution.

Project description:Cancers arise through the acquisition of oncogenic mutations and grow by clonal expansion1,2. Here we reveal that most mutagenic DNA lesions are not resolved into a mutated DNA base pair within a single cell cycle. Instead, DNA lesions segregate, unrepaired, into daughter cells for multiple cell generations, resulting in the chromosome-scale phasing of subsequent mutations. We characterize this process in mutagen-induced mouse liver tumours and show that DNA replication across persisting lesions can produce multiple alternative alleles in successive cell divisions, thereby generating both multiallelic and combinatorial genetic diversity. The phasing of lesions enables accurate measurement of strand-biased repair processes, quantification of oncogenic selection and fine mapping of sister-chromatid-exchange events. Finally, we demonstrate that lesion segregation is a unifying property of exogenous mutagens, including UV light and chemotherapy agents in human cells and tumours, which has profound implications for the evolution and adaptation of cancer genomes.

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NUDT21 Shapes Macrophage Transcriptomes through alternative polyadenylation in ARDS

Project description:NUDT21 Shapes Macrophage Transcriptomes through alternative polyadenylation in ARDS

| PRJNA1242320 | ENA

Pervasive epigenetic effects of Drosophila euchromatic transposable elements impact their evolution

Project description:Pervasive epigenetic effects of Drosophila euchromatic transposable elements impact their evolution

| PRJNA373904 | ENA

Coordinated Gene Family Evolution Shapes the Genome of Dimorphic Organisms

Project description:Coordinated Gene Family Evolution Shapes the Genome of Dimorphic Organisms

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Project description:Optineurin Shapes Basal and LPS-Induced Transcriptomes in BV2 Microglia

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Pervasive epigenetic effects of Drosophila euchromatic transposable elements impact their evolution [ChIP-seq]

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