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Streptomyces

ABSTRACT: Isolates from the genus Streptomyces. Raw sequence reads

PROVIDER: PRJNA353868 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5030430.fastq.gz	Fastqsanger.gz
	SRR5030440.fastq.gz	Fastqsanger.gz
	SRR5030450.fastq.gz	Fastqsanger.gz
	SRR5030460.fastq.gz	Fastqsanger.gz
	SRR5030470.fastq.gz	Fastqsanger.gz

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Streptomyces

Project description:Isolates belonging to the genus Streptomyces - Raw sequence reads

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Identification of the Streptomyces WblA regulon reveals drastic effects on development and specialised metabolism

Project description:Specialised metabolites made by the genus Streptomyces form the basis of 55% of clinically used antibiotics as well as cancer therapeutics, immunosuppressants and other anti-infectives. Streptomyces venezuelae is a model for the genus because it is fast-growing, sporulates in liquid culture within 24 hours and coordinates production of the antibiotic chloramphenicol with sporulation. In this work we demonstrate that the conserved orphan response regulator OrrA directly controls the production of the conserved WhiB-like protein WblA which in turn binds to 90 target gene promoters, including genes required for aerial hyphae production and sporulation. We provide evidence that WblA directly controls the production of AdpA and BldN, key developmental regulators that are required for entry into sporulation and show that the cellular levels of the key developmental regulators AdpA, BldM, BldN, RsbN, WhiA, WhiB and WhiD are significantly altered in a ∆wblA mutant. Proteins encoded by 32 of the 33 predicted specialised metabolite biosynthetic gene clusters in S. venezuelae are also significantly affected by loss of WblA and we show that the ∆wblA mutant over produces the antibiotic chloramphenicol. This is the first time the WblA regulon has been defined in the genus Streptomyces and is consistent with previous reports that deletion of wblA has pleiotropic effects on antibiotic production and sporulation in diverse Streptomyces species.

2025-08-04 | GSE300101 | GEO

Two-component signal transduction systems in Streptomyces and related organisms

Project description:Two component sensor-response regulator systems (TCSs) are very common in the genomes of the Streptomyces species that have been fully sequenced to date. It has been suggested that this large number is an evolutionary response to the variable environment that Streptomyces encounter in soil. Notwithstanding this, TCSs are also more common in the sequenced genomes of other Actinomycetales when these are compared to the genomes of most other eubacteria. In this study, we have used DNA/DNA genome microarray analysis to compare fourteen Streptomyces species and one closely related genus to Streptomyces coelicolor in order to identify a core group of such systems. This core group is compared to the syntenous and non-syntenous TCSs present in the genome sequences of other Actinomycetales in order to separate the systems into those present in Actinomycetales in general, the Streptomyces specific systems and the species specific systems. Horizontal transfer does not seem to play a very important role in the evolution of the TCS complement analyzed in this study. However, cognate pairs do not necessarily seem to evolve at the same pace, which may indicate the evolutionary responses to environmental variation may be reflected differently in sequence changes within the two components of the TCSs. The overall analysis allowed subclassification of the orphan TCSs and the TCS cognate pairs and identification of possible targets for further study using gene knockouts, gene overexpression, reporter genes and yeast two hybrid analysis.

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Morus alba Raw protein sequence reads

Project description:Morus alba L. Raw protein sequence reads and sequence

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Streptomyces secondary metabolism

Project description:This project aims to discover novel bioactive compounds from Streptomyces isolated from the rhizosphere from wild medicinal plants from Hamedan province, Iran. Proteomics is used to assist in discovery and characterization of the compounds. Streptomyces isolates are grown on ISP-4 medium for three days, proteins were extracted and analysed by shotgun proteomics.

2024-01-04 | PXD041994 | Pride

Global gene transcription analysis in response to changes in chromosome supercoiling in Streptomyces coelicolor

Project description:Here, we address the transcriptional response to both novobiocin-induced rapid chromosome relaxation or long-term topological imbalance, both increased and decreased supercoiling, in environmental antibiotic-producing bacteria belonging to the Streptomyces genus.

2019-06-14 | GSE132702 | GEO

Streptomyces secondary metaboites - strain M1

Project description:In this study, we describe the isolation and identification of Streptomyces isolates collected from traditional medicinal plants’ rhizosphere during a campaign in Hamedan Province, Iran. Traditional medicinal plants represent a rich and unique source for the isolation of Streptomyces and new antimicrobial compounds. This strain was isolated from the rhizosphere of Helichrysum rubicundum

2024-01-04 | PXD042019 | Pride

Streptomyces sp.

Project description:Streptomyces Raw sequence reads

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Project description:Streptomyces roseicoloratus Raw sequence reads

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Project description:Streptomyces sp. Raw sequence reads

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