Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: List of TIAM1 differentially expressed genes in SW620 cells [RNA-seq]

PROVIDER: PRJNA354872 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5052680_1.fastq.gz	Fastqsanger.gz
	SRR5052680_2.fastq.gz	Fastqsanger.gz
	SRR5052690_1.fastq.gz	Fastqsanger.gz
	SRR5052690_2.fastq.gz	Fastqsanger.gz
	SRR5052700_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 72

Similar Datasets

List of TIAM1 differentially expressed genes in SW620 cells [RNA-seq]

Project description:The T lymphoma invasion and metastasis inducing protein 1 (TIAM1) is a guanine nucleotide exchange factor (GEF) that activates the small GTPase RAC1 and regulates a plethora of functions such as cell proliferation, migration, apoptosis and polarity. Recently, we demonstrated that TIAM1 shuttles between the cytoplasm and nucleus. To determine the nuclear role of TIAM1, we performed RNA-seq on SW620 cells transfected either with a specific pre-validated siRNA for TIAM1 (siTIAM1) or a negative control siRNA (siNT) and generated a list of TIAM1 differentially expressed genes. GSEA revealed significant enrichment among TIAM1-regulated genes for YAP-associated molecular signature. To investigate the interplay of TIAM1 with YAP/TAZ we used RNA-seq, generated a list of YAP/TAZ differentially expressed genes from SW620 cells transfected either with specific siRNAs for YAP/TAZ or a negative control siRNA and compared it with the siTIAM1 RNA-seq dataset. Interestingly, we found that 50% of the TAZ/YAP regulated genes were also TIAM1 dependent.

2017-04-26 | GSE90491 | GEO

Investigating TIAM1 in NSCLC (RNA-Seq)

Project description:The T lymphoma invasion and metastasis inducing protein 1 (TIAM1) is a guanine nucleotide exchange factor (GEF) that activates the small GTPase RAC1. We have shown that nuclear TIAM1promotes the migration of NSCLC cells. To investigate the requirement for TIAM1 in regulating gene expression of NSCLC cells, we performed RNA-seq on H441 cells transfected with either siRNA for TIAM1 (siTIAM1) or a control siRNA (siControl) to identify differentially expressed genes.

2023-09-12 | GSE219028 | GEO

Homo sapiens

Project description:Identification of differentially expressed genes between SW480 and SW620 spheroid cultures [mRNA]

| PRJNA352467 | ENA

The inhibitory effect of TIAM1 on TAZ transcriptional activity and TIAM1 differentially expressed genes

Project description:The inhibitory effect of TIAM1 on TAZ transcriptional activity and TIAM1 differentially expressed genes

| PRJNA354867 | ENA

Homo sapiens

Project description:Differentially expressed genes in radioresistant nasopharyngeal cancer cells

| PRJNA100045 | ENA

Homo sapiens

Project description:Differentially expressed genes in metallopanstimulin-1 knockdown cells

| PRJNA140599 | ENA

Homo sapiens

Project description:Identification of differentially expressed miRNAs between SW480 and SW620 spheroid cultures [miRNA]

| PRJNA352468 | ENA

CD133+CD24lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype

Project description:Metastatic human colon carcinoma cell lines LS411N and SW620 were cultured in the presence of increased concentration of 5-FU. The selected stable cell lines (LS411N-5FU-R and SW620-5FU-R) are CD133+ that are resistant to 5-FU. However, FACS-sorted CD133+ cells from LS411N and SW620 are not resistant to 5-FU, suggesting that only a subset of CD133+ cells are 5-FU-resistant colon cancer stem cells. A global gene expression profiling was performed to identify differentiated expressed genes between LS411N-CD133+ cells and LS411N-5FU-R, and between SW620-CD133+ and SW620-5FU-R cells. These differentially expressed genes are potentially responsible for the colon cancer stem cell phenotypes and chemoresistance.

2016-12-20 | GSE76489 | GEO

Whole genome microarray of T lymphoma invasion and metastasis (Tiam1) silenced retinoblastoma Y79 cells

Project description:We hypothesized that Tiam1 is involved in invassiveness of retinoblastoma. The fuctional role of Tiam1 in cell progression and metastasis was tested by siRNA mediated knockdown of Tiam1 in retinoblastoma Y79 cells. The genes de-regulated in response to Tiam1 knockdown was analysed by cDNA microarray in which most of the actin cytoskeleton regulation proteins and apoptotic proteins were de-regulated. our results prove that Tiam1 modulates actin cytoskeleton and cell invasion in retinoblastoma. Retinoblastoma Y79 cells were treated with Tiam1 siRNA for 48hrs and cDNA microarray was performed to analyze the genes regulated by Tiam1 silencing compared to untreated Y79 cells. Experiments were performed in triplicates.

2013-03-31 | E-GEOD-45130 | biostudies-arrayexpress

Homo sapiens

Project description:Identification of differentially expressed genes in LBH589-treated cells

| PRJNA153461 | ENA