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Impact of HypERrlnc Knockdown on the human pericyte transcriptome

ABSTRACT: Impact of HypERrlnc Knockdown on the human pericyte transcriptome

OTHER RELATED OMICS DATASETS IN: GSE92887GSE92888

PROVIDER: PRJNA358751 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5129080_1.fastq.gz	Fastqsanger.gz
	SRR5129080_2.fastq.gz	Fastqsanger.gz
	SRR5129090_1.fastq.gz	Fastqsanger.gz
	SRR5129090_2.fastq.gz	Fastqsanger.gz
	SRR5129081_1.fastq.gz	Fastqsanger.gz

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Impact of HypERrlnc Knockdown on the human pericyte transcriptome

Project description:Pericytes are essential for vessel maturation and endothelial barrier function. Long non-coding RNAs (lncRNAs) regulate endothelial cell function, but their role in pericyte biology remains unexplored. Here we characterize the human pericyte transcriptome following knockdown of lncRNA HypERrlnc (RP11-65J21.3).

2017-08-10 | GSE92887 | GEO

Human tumor pericyte protein mass spectrometry

Project description:Proteomics analysis can reveal the differences of protein expression between mural cells (known as pericytes) from normal adjacent tissues (NPC) and tumors (TPC), implying the effectiveness of pericyte to tumor.

2021-08-24 | PXD026963 | Pride

Baf250A, Brd9 and Baf180 knockdown impact on myoblast transcriptome

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miRNA profiling of human saphenous vein pericyte exosomes

Project description:miRNA profiling of human saphenous vein pericyte exosomes

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Impact of the dopamine transporter knockdown in human colorectal cancer cells

Project description:Here, we performed transcriptome-profiling experiments on control scramble shRNA and shSLC6A3 HCT116 cells to study the impact DAT silencing on gene networks associated with neoplastic stemness. We also treated control HCT116 cells with the DAT agonist vanoxerine (VXN) to identify commonly regulated networks between DAT knockdown and pharmacological antagonism.

2023-11-17 | GSE226324 | GEO

Impact of EWS knockdown on LTBR mediated Gene Activation in human fibroblasts

Project description:Impact of EWS knockdown on LTBR mediated Gene Activation in human fibroblasts

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Circular RNA cPLOD2 regulates pericyte function by targeting KLF4

Project description:Circular RNAs (circRNAs) are generated by back-splicing and control cellular signaling and phenotypes. Pericytes stabilize the capillary structure and play an important role in the formation and maintenance of new blood vessels. Here, we characterized hypoxia-regulated circRNAs in human pericytes and showed that circPLOD2 is induced by hypoxia and regulates pericyte functions. Silencing of circPLOD2 increased pericyte proliferation, endothelial-pericyte interactions and tube formation. Transcriptional profiling of circPLOD2-depleted cells and epigenomic analyses revealed widespread changes in gene expression and identified the regulation of the transcription factor KLF4 as a key effector of these changes. Importantly, overexpression of KLF4 was sufficient to reverse the effects on pericyte proliferation and endothelial-pericyte interactions observed after circPLOD2 depletion. Together, these data reveal a novel function of circPLOD2 in the control of pericyte proliferation and capillary formation and show that circPLOD2-mediated regulation of KLF4 significantly contributes to the transcriptional response to hypoxia.

2023-06-19 | GSE219237 | GEO

Impact of SLC39A9 knockdown in murine melanoma cells with Cdkn2a knockdown

Project description:Impact of SLC39A9 knockdown in murine melanoma cells with Cdkn2a knockdown

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Pericyte sGC signaling dictates tumor vessel formation and tumor microenvironment

Project description:Pericytes and endothelial cells (ECs) are building blocks of blood vessels. While the contributions of ECs to tumor angiogenesis and the tumor microenvironment are well established and multiple drugs that targeting ECs have been developed for clinic use to treat cancers, the underlying mechanisms of pericyte in supporting tumor vessel and in shaping tumor microenvironment remains largely unexplored and no pericyte targeting strategies have been approved yet. This study employs targeted deletion of the NO receptor sGC in pericytes and utilizes single-cell RNA sequencing to elucidate its impact on the tumor microenvironment. The results unveil a disruptive effect on EC-pericyte interactions, subsequently impeding Notch-mediated intercellular crosstalk and prompting extensive transcriptomic reprogramming in both cell types. This vascular alteration further relays to neighboring cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) through paracrine signaling, collectively suppressing tumor growth. Importantly, the inhibition of pericyte sGC has limited influence on quiescent vessels but significantly sensitizes angiogenic vessels to anti-angiogenic treatment. In conclusion, this study underscores the vital role of pericytes in governing tumor vessels and the tumor microenvironment, suggesting that targeting pericyte sGC holds promise for enhancing anti-angiogenic therapy.

2024-02-01 | GSE243313 | GEO

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