Project description:The Acute Respiratory Distress Syndrome (ARDS)/Acute Lung Injury (ALI) was described 30 years ago, yet the interaction between specific sets of genes involved in this syndrome remains incompletely understood. Keywords: disease state analysis
Project description:Proteomic investigation of immune response of Lung Tissue from Lipopolysaccharide-induced Acute Respiratory Distress Syndrome in Tree Shrews
Project description:Ferroptosis in lung epithelium and endothelium contributes to the pathogenesis of acute respiratory distress syndrome (ARDS), a critical and frequently fatal condition marked by acute inflammation and elevated pulmonary vascular permeability. Despite this, there are currently no FDA-approved therapeutics specifically targeting ferroptosis for ARDS management. In this investigation, we identified Dipyridamole (DIPY) as a potent ferroptosis inhibitor in pulmonary epithelial and endothelial cells via screening 259 FDA-approved drugs. The anti-ferroptotic and therapeutic efficacy of DIPY was validated in two ARDS mouse models (LPS-induced acute lung injury and CLP-induced sepsis) and human airway organoids (hAOs).
2024-12-18 | GSE272163 | GEO
Project description:Lung microbiota in the acute respiratory distress syndrome
Project description:Acute respiratory distress syndrome (ARDS) is an acute inflammatory lung injury and one of the serious life-threatening forms of respiratory failure. Alveolar procoagulation and fibrinolytic inhibition constitute the core part of the pathophysiology of ARDS, RUNX1 plays an important role in this pathogenesis. We screened for AKT3, the target gene of RUNX1, using CHIP-seq and verified its binding target by a dual luciferase assay.
2024-01-31 | GSE236748 | GEO
Project description:Transcriptome signatures of neonatal acute respiratory distress syndrome in a prospective cohort of respiratory distress
Project description:In this study, we used blood samples of nine patients with severe SARS-CoV-2 infection either with or without acute respiratory distress syndrome (ARDS) and analyzed them on the Illumina EPIC methylation microarray.
Project description:We aimed to identify endotypes of pediatric acute respiratory distress syndrome (ARDS) using whole blood transcriptomics collected within 24 hours of Berlin ARDS onset in intubated children from CHOP Affy microarray and cluster analysis
Project description:The Acute Respiratory Distress Syndrome (ARDS)/Acute Lung Injury (ALI) was described 30 years ago, yet the interaction between specific sets of genes involved in this syndrome remains incompletely understood. Experiment Overall Design: 13 patients with ALI + sepsis and 21 patients with sepsis alone were recruited from the Medical Intensive Care Unit of the University of Pittsburgh Medical Center between February 2005 and June 2007. Whole blood was obtained from each patient within 48 hours of admission, and RNA was extracted for gene expression profiling, and comparison analysis.
Project description:This dataset contains bulk RNA-sequencing profiles generated from lung tissues of Sprague–Dawley rats subjected to cecal ligation and puncture (CLP)-induced acute respiratory distress syndrome (ARDS), with or without right cervical vagus nerve stimulation (VNS).