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Homo sapiens

ABSTRACT: Circulating tumor DNA reflects treatment response and clonal evolution in chronic lymphocytic leukemia

PROVIDER: PRJNA361191 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5229620_1.fastq.gz	Fastqsanger.gz
	SRR5229620_2.fastq.gz	Fastqsanger.gz
	SRR5229630_1.fastq.gz	Fastqsanger.gz
	SRR5229630_2.fastq.gz	Fastqsanger.gz
	SRR5229640_1.fastq.gz	Fastqsanger.gz

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A dataset of sequential DNA methylation profiles (2 timepoints) of 10 patients with chronic lymphocytic leukemia

Project description:Clonal and subclonal evolution is involved in the progression of chronic lymphocytic leukemia (CLL). Evolution can work to select not only genetic mutations, but also epigenetic states. Here we performed a long-term longitudinal DNA methylation profiling study of CLL patients to look for associations of epigenetic evolution to different disease courses. In line with the genetic data, large-scale methylation evolution was not present in any of the evaluated long-term untreated (n = 3) and relapsed (n = 2) patients displaying clonal changes of linear type while 3 of the 5 examined refractory patients featured profound changes in DNA methylation.

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Project description:Clonal evolution, genomic drivers, and effects of therapy in chronic lymphocytic leukemia

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Genetic Aberrations and Subclonal Structure Impact Chronic Lymphocytic Leukemia

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