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Mus musculus

ABSTRACT: Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells

PROVIDER: PRJNA362614 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5189910.fastq.gz	Fastqsanger.gz
	SRR5189911.fastq.gz	Fastqsanger.gz
	SRR5189912.fastq.gz	Fastqsanger.gz
	SRR5189913.fastq.gz	Fastqsanger.gz
	SRR5189914.fastq.gz	Fastqsanger.gz

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Similar Datasets

Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells

Project description:Lymphoid tissue inducer (LTi) cells are regarded as a subset of innate lymphoid cells (ILCs). However, these cells are not derived from the ILC common progenitor, which generates other ILC subsets and is defined by the expression of the transcription factor PLZF. Here we examined transcription factor(s) determining the fate of LTi progenitor versus non-LTi ILC progenitor. Conditional deletion of Gata3 resulted in the loss of PLZF+ non-LTi progenitors but not the LTi progenitors that expressed the transcription factor RORγt. Consistently, PLZF+ non-LTi progenitors expressed high amounts of GATA3 whereas GATA3 expression was low in RORγt+ LTi progenitors. The generation of both progenitors required the transcriptional regulator Id2, which defines the common helper-like innate lymphoid progenitor, but not cytokine signaling. Nevertheless, low GATA3 expression was necessary for the generation of functionally mature LTi cells. Thus, differential expression of GATA3 determines the fates and functions of distinct ILC progenitors.

2019-12-24 | GSE93863 | GEO

Mus musculus

Project description:Group 3 innate lymphoid cells continuously require the transcription factor GATA3 after commitment

| PRJNA290564 | ENA

The transcription factor GATA3 is critical for the development of all IL-7Ra-expressing innate lymphoid cells (ILCs) and maintenance of type 2 ILCs

Project description:Innate lymphoid cells (ILCs) play critical roles during innate immune responses to pathogens and lymphoid organ development. IL-7Ra+ ILC subsets, similar to T helper (Th) cell subsets, produce distinctive effector cytokines. The molecular control of IL-7Ra+ ILC development and maintenance has yet to be dissected. Here we report that GATA3 is indispensable for the development of all IL-7Ra+ ILC subsets and T cells. Gata3 conditional deficient mice have no lymph nodes and are susceptible to Citrobactor rodentium infection. Genome-wide gene analyses indicate that GATA3 regulates similar set of cytokines and receptors in ILC2s and Th2 cells and is critical for the maintenance of ILC2s. Thus, GATA3 plays parallel roles in establishing and regulating both adaptive and innate lymphocytes. To identify GATA3 regulated genes in type 2 innate lymphoid cells by tamoxifen-mediated acute deletion of Gata3 gene.

2014-03-13 | E-GEOD-47851 | biostudies-arrayexpress

The transcription factor NFIL3 is necessary and sufficient to specify the ILC fate in lymphoid progenitors [RNA-seq - ex vivo, Nfil3]

Project description:Helper innate lymphoid cells (ILC) play important functions in immunity and tissue homeostasis, but their development remains poorly understood. In this study, we identified NFIL3 as the earliest known requirement during ILC development. Forced expression of NFIL3 in mouse lymphoid progenitors in vitro triggered the staged expression of downstream transcription factors including Tcf7, Gata3, Zbtb16 and Id2 that are implicated in ILC development. Thus, NFIL3 resides at the apex of a hierarchy of transcription factors important for innate lymphocyte development, and is necessary and sufficient to impose the innate lymphoid cell fate.

2025-10-30 | GSE291075 | GEO

The transcription factor NFIL3 is necessary and sufficient to specify the ILC fate in lymphoid progenitors [CUT&RUN]

2025-10-30 | GSE291321 | GEO

The transcription factor NFIL3 is necessary and sufficient to specify the ILC fate in lymphoid progenitors [DNase-seq]

2025-10-30 | GSE291319 | GEO

The transcription factor NFIL3 is necessary and sufficient to specify the ILC fate in lymphoid progenitors [scRNA-seq]

2025-10-30 | GSE291317 | GEO

The transcription factor NFIL3 is necessary and sufficient to specify the ILC fate in lymphoid progenitors [RNA-seq - Tox]

2025-10-30 | GSE291316 | GEO

The transcription factor NFIL3 is necessary and sufficient to specify the ILC fate in lymphoid progenitors [RNA-seq - Il7rLT]

2025-10-30 | GSE291076 | GEO

Multi-transcription factor reporter mice delineate early precursors to the LTi and ILC lineages

Project description:Transcription factor (TF) reporter mice have proved integral to the characterization of murine innate lymphoid cell (ILC) development and function. Here, we implemented a CRISPR/Cas9-generated combinatorial reporter approach for the simultaneous resolution of several key TFs throughout ILC development in both the fetal liver and adult bone marrow. We demonstrate that the Tcf7-expressing early innate lymphoid progenitor (EILP) and the common helper innate lymphoid progenitor (CHILP) both contain a heterogeneous mixture of committed ILC and Lymphoid Tissue-inducer (LTi) precursors, rather than a shared precursor to these lineages. Moreover, the earliest specified precursor to the LTi lineage was identified upstream of these populations, prior to the expression of Tcf7. These findings match dynamic changes in chromatin accessibility associated with the expression of key TFs (ie. Gata3 and Rorc), highlighting the distinct origins of ILC and LTi lineages at the epigenetic and functional levels, and provide a revised map for ILC development.

2020-09-28 | GSE150763 | GEO

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