Project description:The liver of dairy cows naturally displays a series of metabolic adaptation during the periparturient period in response to the increasing nutrient requirement of lactation. The hepatic adaptation is partly regulated by insulin resistance and it is affected by the prepartal energy intake level of cows. We aimed to investigate the metabolic changes in the liver of dairy cows during the periparturient at gene expression level and to study the effect of prepartal energy level on the metabolic adaptation at gene expression level.B13:N13
Project description:Heat stress is a critical environmental factor that adversely affects the health and productivity of cattle. It leads to substantial declines in productivity and compromises immune function, thereby increasing susceptibility to disease. Crossbred cattle (Bos indicus × Bos taurus) are known for their enhanced productivity. However, they are relatively vulnerable to environmental stressors. In recent years, the intensification of global warming and associated climatic extremes has further heightened their risk of heat stress. In this context, the present study investigated the underlying biological responses to heat stress through genome-wide expression analysis in Vrindavani crossbred cattle. The results identified sets of genes activated during heat stress and subsequent functional characterization revealed key molecular mechanisms of thermal stress response in these animals.
