Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mobiluncus mulieris

ABSTRACT: Mobiluncus mulieris overview

PROVIDER: PRJNA37347 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR016840.fastq.gz	Fastqsanger.gz
	SRR063798.fastq.gz	Fastqsanger.gz
	SRR089521.fastq.gz	Fastqsanger.gz
	SRR10918246_subreads.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Mobiluncus mulieris

Project description:Mobiluncus mulieris Genome sequencing and assembly

| PRJNA625902 | ENA

Mobiluncus curtisii

Project description:Mobiluncus curtisii overview

| PRJNA37499 | ENA

Mobiluncus sp.

Project description:Mobiluncus sp. Genome sequencing and assembly

| PRJNA561908 | ENA

Mobiluncus curtisii

Project description:Mobiluncus curtisii Genome sequencing and assembly

| PRJNA625901 | ENA

Domain structure and cross-linking in a giant adhesin from the Mobiluncus mulieris bacterium.

Project description:Cell-surface proteins known as adhesins enable bacteria to colonize particular environments, and in Gram-positive bacteria often contain autocatalytically formed covalent intramolecular cross-links. While investigating the prevalence of such cross-links, a remarkable example was discovered in Mobiluncus mulieris, a pathogen associated with bacterial vaginosis. This organism encodes a putative adhesin of 7651 residues. Crystallography and mass spectrometry of two selected domains, and AlphaFold structure prediction of the remainder of the protein, were used to show that this adhesin belongs to the family of thioester, isopeptide and ester-bond-containing proteins (TIE proteins). It has an N-terminal domain homologous to thioester adhesion domains, followed by 51 immunoglobulin (Ig)-like domains containing ester- or isopeptide-bond cross-links. The energetic cost to the M. mulieris bacterium in retaining such a large adhesin as a single gene or protein construct suggests a critical role in pathogenicity and/or persistence.

| S-EPMC10619420 | biostudies-literature

Mobiluncus mulieris 28-1

Project description:reference genome for the Human Microbiome Project

| PRJNA34103 | ENA

Mobiluncus mulieris ATCC 35239

Project description:Reference genome for the Human Microbiome Project

| PRJNA51375 | ENA

Mobiluncus mulieris ATCC 35243

Project description:Reference genome for the Human Microbiome Project

| PRJNA34633 | ENA

Mobiluncus mulieris FB024-16

Project description:Reference genome for Human Microbiome Project

| PRJNA51063 | ENA

Extracellular vesicles from vaginal Gardnerella vaginalis and Mobiluncus mulieris contain distinct proteomic cargo and induce inflammatory pathways.

Project description:Colonization of the vaginal space with bacteria such as Gardnerella vaginalis and Mobiluncus mulieris is associated with increased risk for STIs, bacterial vaginosis, and preterm birth, while Lactobacillus crispatus is associated with optimal reproductive health. Although host-microbe interactions are hypothesized to contribute to reproductive health and disease, the bacterial mediators that are critical to this response remain unclear. Bacterial extracellular vesicles (bEVs) are proposed to participate in host-microbe communication by providing protection of bacterial cargo, delivery to intracellular targets, and ultimately induction of immune responses from the host. We evaluated the proteome of bEVs produced in vitro from G. vaginalis, M. mulieris, and L. crispatus, identifying specific proteins of immunologic interest. We found that bEVs from each bacterial species internalize within cervical and vaginal epithelial cells, and that epithelial and immune cells express a multi-cytokine response when exposed to bEVs from G. vaginalis and M. mulieris but not L. crispatus. Further, we demonstrate that the inflammatory response induced by G. vaginalis and M. mulieris bEVs is TLR2-specific. Our results provide evidence that vaginal bacteria communicate with host cells through secreted bEVs, revealing a mechanism by which bacteria lead to adverse reproductive outcomes associated with inflammation. Elucidating host-microbe interactions in the cervicovaginal space will provide further insight into the mechanisms contributing to microbiome-mediated adverse outcomes and may reveal new therapeutic targets.

| S-EPMC10957959 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data