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Rattus norvegicus

ABSTRACT: The effect of TAZ-K in neonatal rat cardiomyocytes

PROVIDER: PRJNA376527 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5280060.fastq.gz	Fastqsanger.gz
	SRR5280061.fastq.gz	Fastqsanger.gz
	SRR5280056.fastq.gz	Fastqsanger.gz
	SRR5280057.fastq.gz	Fastqsanger.gz
	SRR5280058.fastq.gz	Fastqsanger.gz

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The effect of TAZ-K in neonatal rat cardiomyocytes

Project description:Accumulating evidence suggests that new cardiomyocytes are generated from existing cardiomyocytes at a low rate throughout life. This limited regenerative capacity is unable to restore cardiac function after substantial cardiac damage; thus, small molecules have been examined for their ability to enhance the replication of existing cardiomyocytes. A novel compound TAZ-K promoted cardiomyocyte proliferation, therefore, we analyzed the effect of TAZ-K on gene expression in neonatal rat cardiomyocytes. Gene expression involved in cell cycle, anti-oxidant and anti-apoptosis was up-regulated. Thus, TAZ-K may have multifaceted effects and provide a treatment strategy that complements current therapies for patients with myocardial infarction.

2018-10-31 | GSE95274 | GEO

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