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Phase II Therapeutic Trial of Mexiletine in Non-Dystrophic Myotonia (IND #77,021) CINCH 5306

ABSTRACT: Phase II Therapeutic Trial of Mexiletine in Non-Dystrophic Myotonia (IND #77,021) CINCH 5306

PROVIDER: PRJNA377373 | ENA |

REPOSITORIES: ENA

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Project description:Phase II Therapeutic Trial of Mexiletine in Non-Dystrophic Myotonia (IND #77,021) CINCH 5306

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Project description:Therapeutic Trial of Potassium and Acetazolamide in Andersen-Tawil Syndrome CINCH 5305

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Comparison of IND induced vs. mock treated seedlings: Transcriptome profiling upon induction of the transcription factor IND

Project description:rs10-03_ind - comparison of ind induced vs mock treated seedlings - Identification of miRNAs regulated by IND - Transgenic seeds containing an IND transgene under the control of a dexamethasone inducible promoter were germinated and grown in liquid Murashige/Skoog medium under a 16h light/8h darkness light regime. After seven days of growth, seedlings were either mock-treated or treated with 10 micromolar dexamethasone for 24 hours.

2011-05-12 | GSE28898 | GEO

Comparison of IND induced vs. mock treated seedlings: Transcriptome profiling upon induction of the transcription factor IND

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Project description:Fruit dehiscence is an essential developmental process of some economic crops that impacts dramatically on crop yields and involves altered regulation of thousands of genes, ind-6 gene is a transcription factor play important role during fruit dehiscence. Gene expression were examined in wild-type and ind-6 mutants at three development stages of fruit dehiscence to explore the molecular mechanism of ind-6 in fruit dehiscence. We used microarrays to examine changes in gene expression during fruit dehiscence and identified distinct classes of up- and down-regulated genes in wild-type and ind-6 mutant genotypes.

2015-12-28 | GSE66672 | GEO

Phase 1 CX-5461 Trial (Canadian Cancer Trials Group Trial IND.231)

Project description:CX-5461 is a G-quadruplex stabilizer that exhibits synthetic lethality in homologous recombination (HR) deficient models. In this multicentre Phase Ib trial in patients with solid tumors, 40 patients were treated across 10 dose levels (50 - 650 mg/m2) to determine the recommended phase II dose (RP2D), and evaluate safety, tolerability, pharmacokinetics. Defective HR was explored as a predictive biomarker. CX-5461 was generally well tolerated, with a RP2D of 475 mg/m2 d1, 8 and 15 every 4 weeks, and dose limiting toxicities of phototoxicity. Responses were observed in 10% of patients, primarily in patients with defective HR (ORR 14%). Reversion mutations in PALB2 and BRCA2 were detected on progression following initial response in germline carriers, confirming the underlying synthetic lethal mechanism. In vitro characterization of UV sensitization showed this toxicity is related to the CX-5461 chemotype, independent of G4 synthetic lethality. These results establish clinical proof-of-concept for this first-in class G4 stabilizer.

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Transcriptome analysis of genes regulated by INDEHISCENT (IND) transcription factor under the control of the 35S promoter after treatment with auxin

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