Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA378483 | ENA |
REPOSITORIES: ENA
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2018-09-07 | GSE95806 | GEO
Project description:DNA from tumors of 10 male mice were competitively hybridized with DNA from liver samples from the same mouse on NimbleGen CGH arrays to assess copy number changes in the tumors. Four of the mice were wildtype for Acd (ortholog of human TPP1), 2 of which were p53-/- and 2 of which were p53-/+. The other 6 mice were homozygous for the mutant acd allele of Acd. 3 of these mice were p53-/- and the other 3 were p53-/+. Mice were crosses from double heterozygote parental mice. These parental mice were crosses of heterozygous Acd mutant mice (in a mixed DW/JxCAST/Ei background) with heterozygous null p53 mice (C57BL6/J; Trp53-tm1Tyj).
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Project description:PURPOSE: To provide a detailed gene expression profile of the normal postnatal mouse cornea. METHODS: Serial analysis of gene expression (SAGE) was performed on postnatal day (PN)9 and adult mouse (6 week) total corneas. The expression of selected genes was analyzed by in situ hybridization. RESULTS: A total of 64,272 PN9 and 62,206 adult tags were sequenced. Mouse corneal transcriptomes are composed of at least 19,544 and 18,509 unique mRNAs, respectively. One third of the unique tags were expressed at both stages, whereas a third was identified exclusively in PN9 or adult corneas. Three hundred thirty-four PN9 and 339 adult tags were enriched more than fivefold over other published nonocular libraries. Abundant transcripts were associated with metabolic functions, redox activities, and barrier integrity. Three members of the Ly-6/uPAR family whose functions are unknown in the cornea constitute more than 1% of the total mRNA. Aquaporin 5, epithelial membrane protein and glutathione-S-transferase (GST) omega-1, and GST alpha-4 mRNAs were preferentially expressed in distinct corneal epithelial layers, providing new markers for stratification. More than 200 tags were differentially expressed, of which 25 mediate transcription. CONCLUSIONS: In addition to providing a detailed profile of expressed genes in the PN9 and mature mouse cornea, the present SAGE data demonstrate dynamic changes in gene expression after eye opening and provide new probes for exploring corneal epithelial cell stratification, development, and function and for exploring the intricate relationship between programmed and environmentally induced gene expression in the cornea. Keywords: other
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