Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Supraorbital cranial mesenchyme with ectoderm upon the deletion of β-catenin

ABSTRACT: Supraorbital cranial mesenchyme with ectoderm upon the deletion of β-catenin

PROVIDER: PRJNA379961 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5364360_1.fastq.gz	Fastqsanger.gz
	SRR5364360_2.fastq.gz	Fastqsanger.gz
	SRR5364361_1.fastq.gz	Fastqsanger.gz
	SRR5364361_2.fastq.gz	Fastqsanger.gz
	SRR5364362_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 17

Similar Datasets

H3K27me3 enrichment in the supraorbital cranial mesenchyme with ectoderm upon the deletion of β-catenin

Project description:H3K27me3 enrichment in the supraorbital cranial mesenchyme with ectoderm upon the deletion of β-catenin

2019-03-01 | GSE96604 | GEO

Gene expression changes in the supraorbital cranial mesenchyme after beta-catenin deletion in vivo

Project description:Goal of this study was to examine gene expression changes upon conditional deletion of beta-catenin at e13.5 cranial mesenchyme.

2019-03-01 | GSE96871 | GEO

Supraorbital cranial mesenchyme with ectoderm upon the deletion of β-catenin

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-03-01 | GSE96872 | GEO

Ectoderm and mesenchyme gene expression in the developing mouse face

Project description:This investigation provides a robust multi-dimensional compendium of gene expression data relevant to mouse facial development. It profiles the transcriptome ofectoderm and mesenchyme from the three facial prominences in a time series encompassing their growth and fusion. Analysis of the dataset identified more than 8000 differentially expressed genes comprising dramatically different ectoderm and mesenchyme programs. The mesenchyme programs included many genes identified in earlier analyses as well hundreds of genes not previously implicated in craniofacial development. The ectoderm programs included over a thousand genes that highlight epithelial structure, cell-cell interactions and signaling. The dataset includes 45 .cel files, DABG probability and RMA log2 expression values for each probeset, and statistics for 9457 probesets representing 8575 genes. 45 total samples, with 15 conditions sampling three ages (E10.5, E11.5, E12.5), three facial prominences (mandibular, maxillary and fronto-nasal) and two tissue layers (ectoderm or mesenchyme), with 3 biological replicates per condition. Differential expression was determined after median filter for variance with three-way ANOVA, Benjamini-Hochberg multiple testing correction

2014-10-10 | E-GEOD-62214 | biostudies-arrayexpress

Ectoderm and mesenchyme gene expression in the developing mouse face

2014-10-10 | GSE62214 | GEO

EMG1 cooperates with GRHL3 in β-catenin–mediated surface ectoderm differentiation to regulate neural tube closure

Project description:Grainyhead-like transcription factor 3 (GRHL3) directs surface ectoderm differentiation under the control of the canonical Wnt/β-catenin pathway. However, the molecular mechanisms that control nuclear GRHL3 expression through β-catenin are not fully understood. Here, we show that the essential for mitotic growth 1 (EMG1) protein constitutes a protein complex with GRHL3, and that EMG1 is required for correct nuclear localization of GRHL3, and for activation of the canonical Wnt signaling pathway. Conditional knockout mutation of Emg1 in the GRHL3-positive surface ectoderm causes neural tube defects at the level of the spinal cord, i.e. spina bifida. Additionally, the severity of compound mutant phenotypes of the Emg1 and Grhl3 genes indicates that they interact genetically in neurulation and palate development. These lines of evidence demonstrate that EMG1 cooperates with GRHL3 in β-catenin–mediated surface ectoderm differentiation. Since the EMG1 mutation causes Bowen-Conradi syndrome and the GRHL3 mutation causes Van der Woude syndrome 2, both of which are associated with neural tube dysplasia and cleft palate, our study will help to better understand the pathogenic mechanisms of these two human genetic diseases.

2025-07-01 | PXD056807 | JPOST Repository

EMG1 cooperates with GRHL3 in β-catenin–mediated surface ectoderm differentiation to regulate neural tube closure

2025-07-02 | GSE280197 | GEO

Cellular Decoding of Simultaneous Cranial Mesenchyme and Osseous Architecture Reconstruction by Scaffolds

Project description:Cellular Decoding of Simultaneous Cranial Mesenchyme and Osseous Architecture Reconstruction by Scaffolds

| PRJNA1048370 | ENA

Transcriptional profiling to compare gene expression in supraorbital mesenchyme (SOM) and early migration mesenchyme (EMM) of wild type mouse embryos

Project description:During embryonic development, the mesenchyme surrounding the brain (cranial mesenchyme) gives rise to several structures such as the meninges, calvaria, and the dermis of the scalp. It has been known that the two regions within the cranial mesenchyme, namely, SOM on the basolateral side and EMM on the apical side of the head, have different developmental fates. However, the molecular genetic basis underlying this difference had been unclear. To address this question, we sought to identify genes differentially expressed between EMM and SOM. Through RNAseq, we identified 1095 genes with higher expression in EMM than in SOM, and 398 genes with higher expression in SOM than in EMM (fold change>2, p<0.001, base mean count>50).

2019-08-03 | GSE128379 | GEO

Mus musculus

Project description:H3K27me3 enrichment in the supraorbital cranial mesenchyme with ectoderm upon the deletion of β-catenin

| PRJNA379968 | ENA