Project description:Gene expression profiles of human cell (THP-1) lines exposed to a novel Daboiatoxin (DbTx) isolated from Daboia russelli russelli, and specific cytokines and inflammatory pathways involved in acute infection caused by Burkholderia pseudomallei. Keywords: Melioidosis, Burkholderia pseudomallei, Daboiatoxin, Cytokines, Inflammation.
Project description:The proteome of Muscle Tissue of Threatened Indian walking catfish, Clarias magur (Hamilton 1822) was studied to understand muscle protein expressed.
Project description:The proteome of Muscle Tissue of Threatened Indian walking catfish, Clarias magur (Hamilton 1822) was studied to understand muscle protein expressed.
Project description:We report the methylome sequencing and annotation of Burkholderia pseudomallei D286 based on high-throughput profiling using PacBio SMRT technology
Project description:We report the application of single-molecule-based sequencing technology for high-throughput profiling of DNA methylations in Burkholderia pseudomallei.
Project description:Burkholderia mallei and Burkholderia pseudomallei are both potential biological threats agents. Melioidosis caused by B. pseudomallei is endemic in Southeast Asia and Northern Australia, while glanders caused by B. mallei infections are rare. Here we studied the proteomes of different B. mallei and B. pseudomallei isolates to determine species specific characteristics. Analyzing the expressed proteomes of B. mallei and B. pseudomallei revealed differences between B. mallei and B. pseudomallei but also between isolates from the same species. Expression of multiple virulence factors and proteins of several PKS/NRPS clusters was demonstrated. Proteome analysis can be used not only to identify bacteria but also to characterize the expression of important factors that putatively contribute to pathogenesis of B. mallei and B. pseudomallei.
Project description:The proteome of Muscle Tissue of Threatened Indian walking catfish, Clarias magur (Hamilton 1822) was studied to understand muscle protein expressed under abiotic temperature stress. The control samples partial sequence can be accessed by PXD027562 and complete sequence by PXD028115 DOI: 10.6019/PXD028115