Project description:Gene expression profiles of human cell (THP-1) lines exposed to a novel Daboiatoxin (DbTx) isolated from Daboia russelli russelli, and specific cytokines and inflammatory pathways involved in acute infection caused by Burkholderia pseudomallei. Keywords: Melioidosis, Burkholderia pseudomallei, Daboiatoxin, Cytokines, Inflammation.
Project description:The proteome of Muscle Tissue of Threatened Indian walking catfish, Clarias magur (Hamilton 1822) was studied to understand muscle protein expressed.
Project description:The proteome of Muscle Tissue of Threatened Indian walking catfish, Clarias magur (Hamilton 1822) was studied to understand muscle protein expressed.
Project description:We report the application of single-molecule-based sequencing technology for high-throughput profiling of DNA methylations in Burkholderia pseudomallei.
Project description:We report the methylome sequencing and annotation of Burkholderia pseudomallei D286 based on high-throughput profiling using PacBio SMRT technology
Project description:Burkholderia pseudomallei is a Gram-negative pathogen responsible for melioidosis, a life-threatening disease throughout the region of Southeast Asia. LysR-type transcriptional regulators (LTTRs) are key regulators of bacterial virulence and metabolism, yet many remain uncharacterized. This study investigates the function of a novel LTTR, UKMD286_5923, in B. pseudomallei UKM D286. A deletion mutant was constructed, and transcriptomic analysis via RNA sequencing identified 45 upregulated and 22 downregulated genes in the mutant compared to the wild type. Functional enrichment analysis highlighted significant roles in nitrogen metabolism, host entry, and transcriptional regulation. Biofilm formation assays revealed increased biofilm production in the mutant, suggesting a regulatory role in bacterial adhesion.
Project description:The proteome of Muscle Tissue of Threatened Indian walking catfish, Clarias magur (Hamilton 1822) was studied to understand muscle protein expressed under abiotic temperature stress. The control samples partial sequence can be accessed by PXD027562 and complete sequence by PXD028115 DOI: 10.6019/PXD028115