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Sodalis praecaptivus

ABSTRACT: Controlling a Necessary Evil: Quorum Sensing Attenuates Virulence in Sodalis praecaptivus.

PROVIDER: PRJNA382726 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR5445350.fastq.gz	Fastqsanger.gz
	SRR5445360.fastq.gz	Fastqsanger.gz
	SRR5445351.fastq.gz	Fastqsanger.gz
	SRR5445361.fastq.gz	Fastqsanger.gz
	SRR5445352.fastq.gz	Fastqsanger.gz

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Controlling a Necessary Evil: Quorum Sensing Attenuates Virulence in Sodalis praecaptivus.

Project description:Sodalis praecaptivus is a close relative and putative environmental progenitor of the widely distributed, insect-associated, Sodalis-allied symbionts. Mutant strains of S. praecaptivus, lacking critical components of a quorum sensing (QS) apparatus acquire a rapid and potent killing phenotype following microinjection into an insect host. Transcriptomic and genetic analyses indicate that insect killing occurs as a consequence of virulence factors, including insecticidal toxins and enzymes that degrade the insect integument that are normally repressed by QS at high infection densities. This unorthodox method of regulation ensures that virulence factors are only utilized to initiate the insect-bacterial association. Once bacteria reach a sufficient infection density in host tissues, the QS circuit represses the expression of these harmful genes, facilitating a long-lasting and benign association. We discuss the implications of the functionality of this QS system in the context of the establishment and evolution of mutualistic relationships involving these bacteria.

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Indole signaling and (micro)algal auxins decrease the virulence of Vibrio campbellii, a major pathogen of aquatic organisms

Project description:Vibrio campbellii BAA-1116 was used as a Harveyi clade model organism to determine the impact of indole signaling on virulence. Gene expression analysis of V. campbellii grown in LB35 broth with or without 100 μM indole revealed that indole decreased: (1) V. campbellii virulence in shrimp and prawn challenge assays, (2) exopolysaccharide production, and (3) swimming motility. The results also indicated that indole inhibits quorum sensing-regulated bioluminescence and blocks the three-channel quorum sensing system by interfering with quorum sensing signal transduction.

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