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Nakaseomyces glabratus

ABSTRACT: Evolution of Reduced Co-Activator Dependence Led to Target Expansion of a Starvation Response Pathway [Cgla RNA-seq]

PROVIDER: PRJNA382954 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5448450.fastq.gz	Fastqsanger.gz
	SRR5448451.fastq.gz	Fastqsanger.gz
	SRR5448444.fastq.gz	Fastqsanger.gz
	SRR5448445.fastq.gz	Fastqsanger.gz
	SRR5448446.fastq.gz	Fastqsanger.gz

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Nakaseomyces glabratus

Project description:Evolution of Reduced Co-Activator Dependence Led to Target Expansion of a Starvation Response Pathway [Cgla ChIP-seq]

| PRJNA382951 | ENA

Evolution of Reduced Co-Activator Dependence Led to Target Expansion of a Starvation Response Pathway

Project description:Evolution of Reduced Co-Activator Dependence Led to Target Expansion of a Starvation Response Pathway

| PRJNA382942 | ENA

Saccharomyces cerevisiae

Project description:Evolution of Reduced Co-Activator Dependence Led to Target Expansion of a Starvation Response Pathway [Scer ChIP-seq]

| PRJNA382952 | ENA

Saccharomyces cerevisiae

Project description:Evolution of Reduced Co-Activator Dependence Led to Target Expansion of a Starvation Response Pathway [Scer RNA-seq]

| PRJNA382955 | ENA

Nakaseomyces glabratus

Project description:Candida glabrata WT and mutants under iron starvation

| PRJNA331182 | ENA

Nakaseomyces glabratus

Project description:Candida glabrata transcription profile when grown under Niacin starvation or in human urine

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Effect of Nakaseomyces glabratus on BM-MDSCs

Project description:Recent studies demonstrate that the gut mycobiota plays a key role in several tumors’ development. However, the contribution of commensal fungi to prostate cancer initiation and progression remains understudied. Here, we find that Nakaseomyces glabratus (N.glabratus), is enriched in fecal, blood, and tumor samples of a subset of CRPC patients, positively correlating with patients’ poor overall survival. Oral administration of N.glabratus to castrated mice accelerated CRPC development by controlling polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). Mechanistically, androgen deprivation therapy (ADT) increases intestinal permeability, resulting in the leakage of N.glabratus from the gut to the tumor site, where it activates PMN-MDSCs by binding to the Dectin-2 receptor. Treatment of mice with a negatively charged hydrogel blocks N.glabratus translocation to the tumor site, reducing PMN-MDSCs intratumoral infiltration and activation. Taken together, these findings reveal that the gut-to-tumor translocation of commensal fungi contributes to endocrine resistance in CRPC by enhancing the immunosuppressive microenvironment of these tumors.

2025-12-02 | GSE311900 | GEO

Regulation of thiamine and pyruvate decarboxylase genes by Pdc2 in Nakaseomyces glabratus (Candida glabrata) is complex.

Project description:Thiamine (vitamin B1) is essential for glucose catabolism. In the yeast species, Nakaseomyces glabratus (formerly Candida glabrata) and Saccharomyces cerevisiae, the transcription factor Pdc2 (with Thi3 and Thi2) upregulates pyruvate decarboxylase (PDC) genes and thiamine biosynthetic and acquisition (THI) genes during starvation. There have not been genome-wide analyses of Pdc2 binding. Previously, we identified small regions of Pdc2-regulated genes sufficient to confer thiamine regulation. Here, we performed deletion analyses on these regions. We observed that when the S. cerevisiae PDC5 promoter is introduced into N. glabratus, it is thiamine starvation inducible but does not require the Thi3 coregulator. The ScPDC5 promoter contains a 22-bp duplication with an AT-rich spacer between the 2 repeats, which are important for regulation. Loss of the first 22-bp element does not eliminate regulation, but the promoter becomes Thi3 dependent, suggesting cis architecture can generate a Thi3-independent, thiamine starvation inducible response. Whereas many THI promoters only have 1 copy of this element, addition of the first 22-bp element to a Thi3-dependent promoter confers Thi3 independence. Finally, we performed fluorescence anisotropy and chromatin immunoprecipitation sequencing. Pdc2 and Thi3 bind to regions that share similarity to the 22-bp element in the ScPDC5 promoter and previously identified cis elements in N. glabratus promoters. Also, while Pdc2 binds to THI and PDC promoters, neither Pdc2 nor Thi3 appears to bind the evolutionarily new NgPMU3 promoter that is regulated by Pdc2. Further study is warranted because PMU3 is required for cells to acquire thiamine from environments where thiamine is phosphorylated, such as in the human bloodstream.

| S-EPMC11304959 | biostudies-literature

Nakaseomyces glabratus

Project description:Candida Glabrata (PRJCA037442)

| PRJDB34863 | ENA

Nakaseomyces glabratus

Project description:The Candida glabrata transcription factor Stb5p is a negative regulator of ATP-binding cassette transporters

| PRJNA158089 | ENA