Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA384367 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:In advanced malignancies, cancer cells have acquired capabilities to resist a variety of stress-inducing insults. We show that c-Jun N-terminal kinase (JNK) stress signaling is highly active in cancer cells from patients with late stage breast cancer and promotes tumor growth and metastasis in mouse models. Transcriptomic analysis revealed that JNK activity induces genes associated with extracellular matrix (ECM), wound healing and mammary stem cells. The ECM proteins and niche components osteopontin (SPP1) and tenascin C (TNC) are induced by JNK signaling and promote metastatic colonization of the lungs. Notably, treatment with chemotherapeutic drugs induces JNK activity in breast cancer cells, reinforcing the production of SPP1 and TNC. Inhibition of JNK or reduction of SPP1 or TNC expression sensitizes primary tumors and metastases in mice to chemotherapy. In order to investigate cancer cell-response to chemotherapy, we exposed MDA231-LM2 breast cancer cells to the chemotherapeutic agent paclitaxel and performed transcriptomic analysis using Affymetrix microarray.
2018-08-26 | GSE98238 | GEO
Project description:Expression data of ALDH+ breast cancer cells
2025-01-24 | E-GEOD-52327 | ExpressionAtlas
Project description:Expression data from breast cancer tumor-initiating cells
2025-01-24 | E-GEOD-32526 | ExpressionAtlas
Project description:Expression data from breast cancer cells overexpressing NF1-C2
2025-01-24 | E-GEOD-17636 | ExpressionAtlas
Project description:Gene expression data in MDA231-LM2 breast cancer cells cultured as oncospheres
| PRJNA384366 | ENA
Project description:Genes regulated by JNK signaling in MDA231-LM2 breast cancer cells
| PRJNA384365 | ENA
Project description:Expression data from endothelial cells sorted from breast cancer cells MDA-MB231 as compared with normal endothelial cells
2025-01-24 | E-GEOD-48786 | ExpressionAtlas
Project description:Purpose: To identify downstream signaling pathways that mediate functions of GALNT14 Methods: RNAs isolated from MDA231-LM2 cells expressing shCntr or shGALNT14 and MDA231-Par cells expressing pBabe-Hygro control vector or GALNT14 expression vector were analyzed by using an Illumina HiSeq 2500 Conclusions: Our study represents the first transcriptome profile of GALNT14-depleted MDA231-LM2 and GALNT14-overexpressing Par cells.
2019-08-22 | GSE72111 | GEO
Project description:In advanced malignancies, cancer cells have acquired capabilities to resist a variety of stress-inducing insults. We show that c-Jun N-terminal kinase (JNK) stress signaling is highly active in cancer cells from patients with late stage breast cancer and promotes tumor growth and metastasis in mouse models. Transcriptomic analysis revealed that JNK activity induces genes associated with extracellular matrix (ECM), wound healing and mammary stem cells. The ECM proteins and niche components osteopontin (SPP1) and tenascin C (TNC) are induced by JNK signaling and promote metastatic colonization of the lungs. Notably, treatment with chemotherapeutic drugs induces JNK activity in breast cancer cells, reinforcing the production of SPP1 and TNC. Inhibition of JNK or reduction of SPP1 or TNC expression sensitizes primary tumors and metastases in mice to chemotherapy. We used Affymetrix microarrays to analyze the transcriptomic output modulated by JNK activity in a lung metastatic derivative of the MDA-MB-231 breast cancer cell line, MDA231-LM2.
2018-08-26 | GSE98237 | GEO
Project description:CAL-51 breast cancer side population cells
2025-01-24 | E-GEOD-18773 | ExpressionAtlas