Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA386940 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Expression data from pancreatic cancer cell line MiaPaca2
| PRJNA214662 | ENA
Project description:Next-generation sequencing was applied to compare the transcriptom of 1) SW1990 human pancreatic cancer cell lines and its gemcitabine-resistant derivative established with long-term exposure in medium containing 100 nM gemcitabine; 2) TRA-1-81+ cells and TRA-1-81- cells isolated from SW1990 human pancreatic cancer cell line.
2017-03-31 | GSE79953 | GEO
Project description:Expression data from pancreatic cancer cell line MiaPaca2 [control]
| PRJNA214660 | ENA
Project description:Microarray analyses using CD166+ and CD166- pancreatic cancer cell lines from both Panc-1 and SW1990 cells. We carried out microarray analyses using the CD166+ and CD166- separated cells from both Panc-1 and SW1990. The quality of the RNA samples was evaluated using a 2100 Bioanalyzer (Agilent Technologies, Waldbronn, Germany). We used a Human HT-12v4 Expression BeadChip (Illumina, San Diego, CA) for these analyses. The data were analyzed using BeadStudio software version 3.2.3 (Illumina).
2014-02-25 | E-GEOD-55294 | biostudies-arrayexpress
Project description:Expression data from pancreatic cancer cell lines
| PRJNA126617 | ENA
Project description:Expression data from DMOS- or paeoniflorin- treated human pancreatic cancer cell line Capan-1
| PRJNA380866 | ENA
Project description:<p>Alkaliptosis, a pH-dependent form of regulated cell death characterized by impaired lysosomal function and lethal alkalinization, holds promise as a target for cancer therapy. Here, we utilize mass spectrometry-based drug target, transcriptomic screens and lipid metabolomics to explore the metabolic mechanisms underlying alkaliptosis. We reveal CYP51A1, a gene involved in cholesterol synthesis, as a key suppressor of alkaliptosis in pancreatic cancer cells. Inducing alkaliptosis leads to a decrease in endoplasmic reticulum cholesterol levels, subsequently activating SREBF2, a transcription factor responsible for controlling the expression of genes involved in cholesterol biosynthesis. Specifically, SREBF2-driven upregulation of CYP51A1 prevents cholesterol accumulation within lysosomes, leading to TMEM175-dependent lysosomal proton efflux, ultimately resulting in the inhibition of alkaliptosis. In animal models, including xenografts, orthotopic and patient-derived models, the genetic or pharmacological inhibition of CYP51A1 enhances the effectiveness of JTC801 in suppressing pancreatic tumors. These findings demonstrate the key role of the CYP51A1-dependent lysosomal pathway in inhibiting alkaliptosis and highlight its potential as a targetable vulnerability in pancreatic cancer.</p><p><br></p><p><strong>PDAC-PANC1 cell line analysis</strong> is reported in the current study <a href='https://www.ebi.ac.uk/metabolights/MTBLS9283' rel='noopener noreferrer' target='_blank'><strong>MTBLS9283</strong></a>.</p><p><strong>PDAC-SW1990 cell line analysis</strong> is reported in <a href='https://www.ebi.ac.uk/metabolights/MTBLS9288' rel='noopener noreferrer' target='_blank'><strong>MTBLS9288</strong></a>.</p>
2025-02-28 | MTBLS9283 | MetaboLights
Project description:Expression data from 22 Pancreatic Cancer Cell Lines
| PRJNA125881 | ENA
Project description:Gene expression profiling of pancreatic cancer cell PANC-1 and SW1990 when LINC00842 knockdown by CRISPR/Cas9 system. We identified LINC00842 is a novel prognosis related lincRNA in pancreatic cancer and its regulation networks is poorly understood. We used the total RNA from knockdown control and LINC00842-knockdown PANC-1 and SW1990 cells to analyze the differentially expressed genes which were regulated by LINC00842, and further explored the biological processes that LINC00842 may involved.
2021-04-21 | GSE150216 | GEO
Project description:Expression data from human colorectal cancer cell line
| PRJNA362934 | ENA