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Rattus norvegicus

ABSTRACT: Integrative epigenomic analyses of early-life hypothalamic response to augmented maternal care [RNA-seq]

PROVIDER: PRJNA387919 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5597650.fastq.gz	Fastqsanger.gz
	SRR5597645.fastq.gz	Fastqsanger.gz
	SRR5597646.fastq.gz	Fastqsanger.gz
	SRR5597647.fastq.gz	Fastqsanger.gz
	SRR5597648.fastq.gz	Fastqsanger.gz

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Integrative epigenomic analyses of early-life hypothalamic response to augmented maternal care [miRNA]

Project description:The quality of maternal care in early-life plays a crucial role in mammalian neurodevelopment. Augmented maternal care (AMC) is a well-established rodent model of enhanced neonatal care. Rats that have undergone AMC have improved stress resilience and cognition compared with rats that have experienced normal levels of maternal care or adverse neonatal stress. However, the epigenomic basis of long-lived responses to AMC has not been previously explored. Thus, we employed whole-genome bisulfite sequencing (WGBS), RNA-sequencing (RNA-seq), and a multiplex microRNA (miRNA) assay to assess DNA cytosine methylation, gene expression, and miRNA expression, respectively. The integrated results identify a suite of 20 prioritized candidates impacted by AMC. Overall, these results identified AMC-induced regulatory differences in genes related to neurotransmission, neurodevelopment, protein synthesis, and oxidative phosphorylation in addition to the expected stress response genes. Together, these unbiased results represent a key progression in understanding the complex mechanisms underlying the early-life mechanisms for AMC programming stress resiliency.

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The social life of Norway rats (Rattus norvegicus).

Project description:The Norway rat has important impacts on our life. They are amongst the most used research subjects, resulting in ground-breaking advances. At the same time, wild rats live in close association with us, leading to various adverse interactions. In face of this relevance, it is surprising how little is known about their natural behaviour. While recent laboratory studies revealed their complex social skills, little is known about their social behaviour in the wild. An integration of these different scientific approaches is crucial to understand their social life, which will enable us to design more valid research paradigms, develop more effective management strategies, and to provide better welfare standards. Hence, I first summarise the literature on their natural social behaviour. Second, I provide an overview of recent developments concerning their social cognition. Third, I illustrate why an integration of these areas would be beneficial to optimise our interactions with them.

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