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Homo sapiens

ABSTRACT: Phase Separation of Ligand-Activated Enhancers Licenses Cooperative Chromosomal Enhancer Assembly [HiC-seq]

PROVIDER: PRJNA388867 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR5638500_1.fastq.gz	Fastqsanger.gz
	SRR5638500_2.fastq.gz	Fastqsanger.gz
	SRR5638510_1.fastq.gz	Fastqsanger.gz
	SRR5638510_2.fastq.gz	Fastqsanger.gz
	SRR5638520_1.fastq.gz	Fastqsanger.gz

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An eRNA Transcription Checkpoint For Diverse Signal-dependent Enhancer Activation Programs

Project description:The evidence that several signal and ligand-dependent pathways function by activating regulatory enhancer programs suggests that a “checkpoint” strategy may underline activation of some or even many diversely-regulated enhancers. Here, we report a molecular mechanism common to several acute signal- and ligand-dependent enhancer activation programs based on release of a shared eRNA transcription checkpoint. This requires recruitment of a DNA-PKcs-phosphorylated RING finger repressor, KAP1, functioning as a modulator, inhibiting its association with 7SK and E3 SUMO ligase activity on the CDK9 subunit of P-TEFb, facilitating formation of an activated P-TEFb complex, licensing eRNA elongation. Overcoming this checkpoint for signal-dependent enhancer activation occurs in diverse pathways including estrogen receptor α, NF-κB-regulated proinflammatory, androgen receptor and neuronal depolarization. Therefore, a specific strategy required to convert a basal state enhancer P-TEFb complex to an active state to release a conserved checkpoint is apparently employed by several functionally-important signal/ligand-regulated regulatory enhancers to implement the instructions of endocrine/paracrine system

2025-02-21 | PXD056186 | Pride

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