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Homo sapiens

ABSTRACT: RNA-sequencing of shSRC-1 and shNT tamoxifen treated LY2 cells

PROVIDER: PRJNA389214 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5644200_1.fastq.gz	Fastqsanger.gz
	SRR5644200_2.fastq.gz	Fastqsanger.gz
	SRR5644201_1.fastq.gz	Fastqsanger.gz
	SRR5644201_2.fastq.gz	Fastqsanger.gz
	SRR5644202_1.fastq.gz	Fastqsanger.gz

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Homo sapiens

Project description:MeDIP-sequencing of shSRC-1 and shNT tamoxifen treated LY2 cells

| PRJNA389215 | ENA

RNA-sequencing and MeDIP-sequencing of shSRC-1 and shNT tamoxifen treated LY2 cells

Project description:RNA-sequencing and MeDIP-sequencing of shSRC-1 and shNT tamoxifen treated LY2 cells

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HoxC11 ChIP-seq of LY2 Breast Cancer Cell Line

Project description:SRC-1 (NCOA1) is a steroid receptor coactivator that has been associated with various aspects of the progression of breast cancer disease such as tamoxifen resistance, metastasis, cell proliferation and invasiveness. In a tamoxifen resistant breast cancer cell line (LY2), SRC-1 has been found to interact with the developmental transcription factor HoxC11. ChIP-sequencing of HoxC11 in LY2 cells shows where the transcription factor binds throughout the genome. LY2 cells were treated with either tamoxifen or vehicle and immunoprecipitated with anti-Hoxc11

2014-01-14 | E-GEOD-54027 | biostudies-arrayexpress

Homo sapiens

Project description:RNA-sequencing of tamoxifen resistant LY2 cells transfected with siRNA-HOXC11.

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HoxC11 ChIP-seq of LY2 Breast Cancer Cell Line

2014-01-14 | GSE54027 | GEO

Homo sapiens

Project description:Differential expression of microRNA expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells

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Homo sapiens whole blood.

Project description:RNA extracted at 240min. Samples are rRNA depleted. Expression measurement of Homo sapiens genes.

2019-07-31 | GSE114179 | GEO

SRC-1 targets ADAM22: an ER-independent mechanism of tumour progression in endocrine resistance

Project description:We profile the binding of Steroid Receptor Co-activator (SRC1) in LY2 cells, a tamoxifen-resistant cell line, in the presence and absence of tamoxifen using ChIP-sequencing technology. The development of breast cancer resistance to endocrine therapy results from an increase in cellular plasticity leading to the development of a steroid-independent tumour. The p160 steroid coactivataor protein SRC-1, through interactions with developmental proteins and other non-steroidal transcription factors, drives this tumour adaptability. Here, using discovery studies, we identify ADAM22, a non-protease member of the ADAMs family, as a direct, ER-independent target of SRC-1. Molecular, cellular and in vivo studies confirmed SRC-1 as a regulator of ADAM22. At a functional level, a role for ADAM22 in cellular migration and differentiation was observed. In vivo data from a mouse xenograft model indicated that ADAM22 expression was higher in 4-OHT-treated endocrine-resistant tumours than in tumours derived from isogenic, sensitive cells. Furthermore, in breast cancer patients, ADAM22 expression is an independent predictor of poor disease free survival. SRC-1 can function as a molecular switch which converts a steroid-responsive tumour to a steroid-resistant tumour. The ER-independent SRC-1 target ADAM22 is a potential drug target and a companion predictive biomarker in the treatment of endocrine-resistant breast cancer. Examination of SRC-1 binding in LY2 cells in the presence or absence of tamoxifen treatment. 2 replicates each.

2011-11-01 | E-GEOD-28987 | biostudies-arrayexpress

HMGB2 in endocrine resistant breast cancer

Project description:HMGB2 and ER ChIPseq was investigated in the MCF-7 endocrine sensitive and LY2 endocrine resistant cell lines upon treatment with Tamoxifen.

2014-09-18 | E-MTAB-1865 | biostudies-arrayexpress

Homo sapiens Transcriptome or Gene expression

Project description:Asthma is a chronic inflammatory airway disease characterized by airway inflammation and remodeling. The role of 15-oxo-5Z,8Z,11Z,13E-eicosatetraenoic acid (15-oxoETE), a 15-HETE metabolite catalyzed by 15-prostaglandin dehydrogenase (15-PGDH), has been relatively unexplored in asthma. In this study, we used RNA-seq to explore the effect of 15-KETE on the transcriptome of airway epithelial cells, aiming to identify its potential downstream targets and mechanisms of action.

2026-05-21 | GSE325003 | GEO

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