Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: Histamine H3 receptor agonist regulates the expression of inflammation-related genes in kidney and heart of ANS-treated mice

PROVIDER: PRJNA392329 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5767600_1.fastq.gz	Fastqsanger.gz
	SRR5767600_2.fastq.gz	Fastqsanger.gz
	SRR5767610_1.fastq.gz	Fastqsanger.gz
	SRR5767610_2.fastq.gz	Fastqsanger.gz
	SRR5767601_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 50

Similar Datasets

Histamine H3 receptor agonist regulates the expression of inflammation-related genes in kidney and heart of ANS-treated mice

Project description:We found the impaired renal function accompanied with severe cardiac dysfunction in mice co-treated with angiotensin II, nephrectomy and salt (ANS), and identified the increased level of plasma histamine in ANS-treated mice. Interestingly, pro-inflammatory genes were increased in kidneys of ANS-treated animals, which were down-regulated by histamine H3 receptor (H3R) agonist. Purpose: To evaluate the molecular mechanisms underlying the effect of the H3R agonist on the ANS-induced renal and cardiac inflammation, we performed a comprehensive analysis of ANS-mediated gene expression changes with/without H3R agonist in kidneys and hearts using RNA sequencing (RNA-Seq). Results: To investigate differentially expressed genes (false discovery rate (FDR) p<0.05, fold change >2) among three groups, we performed pairwise comparisons of RNA-Seq data using the CLC Genomics Workbench software. In comparison with the control of kidney group, 1,283 (1,010 up- and 273 down-regulated) unique genes were significantly changed in the ANS-treated group. Meanwhile, the data set of ANS-treated kidneys with H3R agonist revealed significant changes in 234 (65 up- and 169 down-regulated) genes as compared with the control groups. In case of hearts, the ANS-treated group revealed that 85 (66 up- and 19 down-regulated) unique genes were significantly changed compared to the control groups. Furthermore, in comparison with the ANS-treated with H3R agonist group, one up-regulated gene was significantly changed in the ANS-treated group.

2019-12-26 | GSE100635 | GEO

ENSG00000260909

Project description:Homo sapiens ENSG00000260909, histamine receptor H3 (HRH3) pseudogene, is expressed in 12 baseline experiment(s);

| ENSG00000260909 | ExpressionAtlas

ENSG00000260909

Project description:Homo sapiens ENSG00000260909, histamine receptor H3 (HRH3) pseudogene, is differentially expressed in 1 experiment(s);

| ENSG00000260909 | ExpressionAtlas

Pharmacology of PPAR isoform agonists on mouse

Project description:Transcriptional consequences of pharmacologic PPAR a, d, & g agonist administration in murine liver, heart, kidney, and skeletal muscle

2015-08-31 | GSE27948 | GEO

E-GEOD-34748

Project description:Intragraft Gene Expression in Positive Crossmatch Kidney Allografts: Ongoing Inflammation Mediates Chronic Antibody-Mediated Injury

2025-01-24 | E-GEOD-34748 | ExpressionAtlas

Transcriptional analysis of organ-specific toxicity induced by a panPPAR agonist in mice: Identification of organ-specific toxicity biomarkers

Project description:In this study, we aim to identify candidate biomarkers which may be useful as surrogate indicators of toxicity for pre-clinical development of panPPAR-agonist drug candidates. Gene expression microarray, histopathology and clinical chemistry data were generated from liver, heart, kidney and skeletal muscles of three groups of mice administered with three different dosages of an experimental pan-peroxisome proliferator-activated receptor (pan-PPAR) agonist, PPM-201, for 14 days. The histopathology and clinical chemistry data were compared with the gene expression analysis and candidate biomarker genes were identified.

2013-02-19 | GSE31561 | GEO

adap1l

Project description:Xenopus tropicalis adap1l, histamine H3 receptor [Source:NCBI gene;Acc:100498398], is expressed in 1 baseline experiment(s);

| ENSXETG00000003880 | ExpressionAtlas

Hrh3

Project description:Rattus norvegicus Hrh3, histamine receptor H3 [Source:RGD Symbol;Acc:620630], is expressed in 4 baseline experiment(s);

| ENSRNOG00000061153 | ExpressionAtlas

Hrh3

Project description:Rattus norvegicus Hrh3, histamine receptor H3 [Source:RGD Symbol;Acc:620630], is differentially expressed in 15 experiment(s);

| ENSRNOG00000061153 | ExpressionAtlas

HRH3

Project description:Monodelphis domestica HRH3, histamine receptor H3 [Source:NCBI gene;Acc:100020722], is expressed in 1 baseline experiment(s);

| ENSMODG00000016705 | ExpressionAtlas