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Pseudogymnoascus destructans

ABSTRACT: Causative agent of the White-Nose Syndrome cutaneous infection, a new species of Geomyces

PROVIDER: PRJNA39271 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
		Other
	SRR029259.fastq.gz	Fastqsanger.gz
	SRR029260.fastq.gz	Fastqsanger.gz
	SRR029261.fastq.gz	Fastqsanger.gz
	SRR031784.fastq.gz	Fastqsanger.gz

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Pseudogymnoascus destructans

Project description:Two distinct host-specialised fungal species cause white-nose disease in bats

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Pseudogymnoascus destructans

Project description:Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America With No Sign of Recombination

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P. destructans secretome analyses

Project description:This data is in support of a study entitled "Characterization of PdCP1, a Serine Carboxypeptidase from P. destructans, the Causal Agent of White-nose Syndrome" by Beekman, C. et al. which is submitted and under review. Data will be released upon acceptance of the publication.

2018-04-30 | MSV000082319 | MassIVE

Collagen-Degrading Peptidase Destructin-1

Project description:This dataset is provided in support of the identification of a collagen-degrading enzyme secreted by the fungus P. destructans. P. destructans is responsible for the disease white nose syndrome, which has infected and killed millions of North American bats. Our manuscript, titled "Destructin-1 is a Collagen-Degrading Endopeptidase Secreted by P. destructans, the Causative Agent of White-Nose Syndrome", is under review, and the data set will be released upon acceptance.

2015-03-23 | MSV000079085 | MassIVE

Transcriptome Analysis of Pseudogymnoascus destructans Under Copper Stress Conditions Reveals Adaptive Responses and Putative Virulence Factors

Project description:Copper (Cu) is an essential metal micronutrient, and a fungal pathogens' ability to thrive in diverse niches across a broad range of bioavailable copper levels is vital for host-colonization and fungal-propagation. Recent transcriptomic studies have imple-mented that trace metal acquisition is important for the propagation of the white nose syndrome (WNS) causing fungus, Pseudogymnoascus destructans, on bat hosts. This report characterizes the P. destructans transcriptional response to Cu-withholding and Cu-over-load stress. We identify 583 differently expressed genes (DEGs) that respond to Cu-with-holding stress and 667 DEGs that respond to Cu-overload stress. We find that P. de-structans the Cu-transporter genes CTR1a and CTR1b, as well as two homologs to Crypto-coccus neoformans Cbi1/BIM1 VC83_03095 (BLP2) and VC83_07867 (BLP3) are highly reg-ulated by Cu-withholding stress. We identify a cluster of genes, VC83_01834 – VC83_01837, that are regulated by Cu bioavailability, which we identify as the Cu Re-sponsive gene Cluster (CRC). We find that chronic exposure to elevated Cu levels leads to an increase in genes associated with DNA repair and DNA replication fidelity. A com-parison of our transcriptomic data sets with P. destructans at WNS fungal infection sites reveals several putative fungal virulence factors that respond to environmental copper stress.

2025-05-20 | GSE296069 | GEO

destructin-1 related files

Project description:This is a training data set for destructin-1 protease digestion of a synthetic peptide library for substrate specificity profiling. Data is related to the following publication: O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ. "Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome." Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7478-83. doi: 10.1073/pnas.1507082112. Epub 2015 May 5. Erratum in: Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):E3152. PMCID: PMC4475985.

2015-11-24 | MSV000079388 | MassIVE

Pseudogymnoascus destructans

Project description:Resequencing of North American isolates of Pseudogymnoascus destructans

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Pseudogymnoascus destructans

Project description:Pseudogymnoascus destructans Raw sequence reads

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Pseudogymnoascus destructans

Project description:Pseudogymnoascus destructans Raw sequence reads

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Pseudogymnoascus destructans transcriptome changes during white-nose syndrome infections.

Project description:White nose syndrome (WNS) is caused by the psychrophilic fungus Pseudogymnoascus destructans that can grow in the environment saprotrophically or parasitically by infecting hibernating bats. Infections are pathological in many species of North American bats, disrupting hibernation and causing mortality. To determine what fungal pathways are involved in infection of living tissue, we examined fungal gene expression using RNA-Seq. We compared P. destructans gene expression when grown in culture to that during infection of a North American bat species, Myotis lucifugus, that shows high WNS mortality. Cultured P. destructans was grown at 10 to 14 C and P. destructans growing in vivo was presumably exposed to temperatures ranging from 4 to 8 C during torpor and up to 37 C during periodic arousals. We found that when P. destructans is causing WNS, the most significant differentially expressed genes were involved in heat shock responses, cell wall remodeling, and micronutrient acquisition. These results indicate that this fungal pathogen responds to host-pathogen interactions by regulating gene expression in ways that may contribute to evasion of host responses. Alterations in fungal cell wall structures could allow P. destructans to avoid detection by host pattern recognition receptors and antibody responses. This study has also identified several fungal pathways upregulated during WNS infection that may be candidates for mitigating infection pathology. By identifying host-specific pathogen responses, these observations have important implications for host-pathogen evolutionary relationships in WNS and other fungal diseases.

| S-EPMC5810475 | biostudies-literature

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