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Omics analysis of transgenic chickens compared with non-transgenic chickens

ABSTRACT: Omics analysis of transgenic chickens compared with non-transgenic chickens

PROVIDER: PRJNA393334 | ENA |

REPOSITORIES: ENA

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Omics analysis of transgenic chickens compared with non-transgenic chickens [genotypes]

Project description:To investigate food safety made from genetically modified organisms and genome editing organism, we researched the difference of the metabolic substances between wild type and transformant in chicken blood by using transcriptome, proteome and metabolome analysis. In this study, we compared the difference of gene expression between wild type and GFP hetero transformant in leukocyte extracted from 1-2 month old female chickens.

2017-07-07 | GSE100879 | GEO

Omics analysis of transgenic chickens compared with non-transgenic chickens [gender]

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Omics analysis of transgenic chickens compared with non-transgenic chickens

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Expression data from hAT1R transgenic and non-transgenic C57BL/6 mouse heart tissue

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Vitreous proteome of transgenic INSC94Y pigs compared to wild type

Project description:INSC94Y transgenic pigs serve as a valuable model for permanent neonatal diabetes mellitus. Through genetically engineered modifications in the insulin (INS) gene, this model presents with impaired insulin secretion, resulting elevated fasting blood-glucose levels (hyperglycemia) [1].One of the severe complications of diabetes mellitus are hypoglycemia-mediated morphological abnormalities in the retina, also described as diabetic retinopathy (DR). Adjacent to the retina lies the vitreous, a gelatinous, highly hydrated matrix, which is important for ocular function and retinal physiology. It contains variety of proteins and signaling molecules, which are useful for the characterization of the biological activity of the vitreous itself, and may help to elucidate molecular processes occurring in the retina, especially under pathophysiological conditions and in disease. To gain insight into the proteomic profile of porcine vitreous and detect possible differences relevant to DR pathogenesis, we used discovery proteomics for analysis of INSC94Y vitreous compared to wild-type controls. Reference: [1] Renner, S.; Braun-Reichhart, C.; Blutke, A.; Herbach, N.; Emrich, D.; Streckel, E.; Wunsch, A.; Kessler, B.; Kurome, M.; Bahr, A.; et al. Permanent neonatal diabetes in INS(C94Y) transgenic pigs. Diabetes 2013, 62, 1505-1511, doi:10.2337/db12-1065.

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