Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: CD95L derived si- and shRNAs kill cancer cells through an RNAi mechanism by targeting survival genes [shL3.shR6.RNAseq.lg]

PROVIDER: PRJNA393938 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5819120_1.fastq.gz	Fastqsanger.gz
	SRR5819120_2.fastq.gz	Fastqsanger.gz
	SRR5819130_1.fastq.gz	Fastqsanger.gz
	SRR5819130_2.fastq.gz	Fastqsanger.gz
	SRR5819140_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 64

Similar Datasets

CD95L derived si- and shRNAs kill cancer cells through an RNAi mechanism by targeting survival genes

Project description:CD95L derived si- and shRNAs kill cancer cells through an RNAi mechanism by targeting survival genes

| PRJNA347649 | ENA

Homo sapiens

Project description:CD95L derived si- and shRNAs kill cancer cells through an RNAi mechanism by targeting survival genes [AGOpulldownRNAseq.sm]

| PRJNA393832 | ENA

Homo sapiens

Project description:CD95L derived si- and shRNAs kill cancer cells through an RNAi mechanism by targeting survival genes [FasLRNAseq.lg]

| PRJNA393897 | ENA

Homo sapiens

Project description:CD95L derived si- and shRNAs kill cancer cells through an RNAi mechanism by targeting survival genes [shL1.RNAseq.lg]

| PRJNA393824 | ENA

CD95L mRNA is toxic to cells [SmallRNA.CD95L.50hrs.HeyA8]

Project description:>80% of a large number of tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death that is characterized by the simultaneous activation of multiple death pathways and preferentially affects transformed and cancer stem cells. We now show that these si/shRNAs kill cancer cells through canonical RNAi by targeting the 3’UTR of critical survival genes in a unique form of off-target effect. We also provide evidence showing that the full length CD95L mRNA is also toxic and produces small Ago-associated RNAs.

2018-09-20 | GSE102780 | GEO

CD95L mRNA is toxic to cells [SmallRNA_CD95L.50hrs.Drosha_ko]

2018-09-20 | GSE102779 | GEO