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Homo sapiens

ABSTRACT: LncRNA NMR knockdown and overexpression in esophageal squamous cell carcinoma cell lines

PROVIDER: PRJNA395325 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5858000_1.fastq.gz	Fastqsanger.gz
	SRR5858000_2.fastq.gz	Fastqsanger.gz
	SRR5858001_1.fastq.gz	Fastqsanger.gz
	SRR5858001_2.fastq.gz	Fastqsanger.gz
	SRR5858002_1.fastq.gz	Fastqsanger.gz

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LncRNA NMR knockdown and overexpression in esophageal squamous cell carcinoma cell lines

Project description:Long noncoding RNAs (lncRNAs) are emerging as key regulators in cancer and play complicate and critical roles in regulating various key biological processes including chromatin modification, transcription and post-transcriptional processing. We identified a novel transcript, lncRNA NMR, which was upregulated in esophageal squamous cell carcinoma (ESCC) and significantly associated with overall survival of ESCC patients and and is identical to ENST00000432429.1 in GENCODE v13 or ENST00000432429.5 in Ensembl release 83. Here, we sought to determine the alterations of trancriptome after shRNA-mediated knockdown and transient overexpression of lncRNA NMR in ESCC KYSE70 and KYSE450 cell lines．

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