Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human nasopharyngeal metagenome

ABSTRACT: human lung and nasopharynx metagenome in HIV-complicated respiratory infection

PROVIDER: PRJNA401429 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6010030.fastq.gz	Fastqsanger.gz
	SRR6010040.fastq.gz	Fastqsanger.gz
	SRR6010050.fastq.gz	Fastqsanger.gz
	SRR6010060.fastq.gz	Fastqsanger.gz
	SRR6010031.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 44

Similar Datasets

human nasopharyngeal metagenome

Project description:Human nasopharynx Metagenome

| PRJNA229922 | ENA

human nasopharyngeal metagenome

Project description:Respiratory bacteria Metagenome

| PRJNA277998 | ENA

RNAseq of human epithelial nasopharyngeal carcinoma cell line Detroit 562, following infection with strains of Streptococcus pneumoniae

Project description:The transcriptomic innate immune response derived from human nasal epithelial cells depends on how Streptococcus pneumoniae colonises the nasopharynx. This study compared three wild type strains and one deficient in pneumolysin to explore the pathways of epithelial activation following a three hour infection in vitro.

2019-05-01 | E-MTAB-7841 | biostudies-arrayexpress

human nasopharyngeal metagenome

Project description:Metatranscriptome study of human respiratory

| PRJNA999612 | ENA

human lung metagenome

Project description:Human respiratory tract mycobiome and alterations in HIV infection and lung disease Targeted Locus (Loci)

| PRJNA241408 | ENA

human nasopharyngeal metagenome

Project description:Human Upper Respiratory Tract Targeted Locus (Loci)

| PRJNA267237 | ENA

human nasopharyngeal metagenome

Project description:Metagenomic sequencing of nasal swabs from acute respiratory infection raw sequence reads

| PRJNA293686 | ENA

Project description:The human nasopharynx microbiome of infants with respiratory syncytial virus infection

| PRJEB20811 | ENA

Contrasting inflammatory signatures in peripheral blood and bronchoalveolar cells reveal compartment-specific effects of HIV infection

Project description:The mechanisms by which HIV increases susceptibility to tuberculosis and other respiratory infections are incompletely understood. We used transcriptomics of paired whole bronchoalveolar lavage (BAL) fluid and peripheral blood mononuclear cells to compare the effect of HIV at the lung mucosal surface and in the peripheral blood. The large majority of HIV-induced differentially expressed genes (DEGs) were specific to either the peripheral or lung mucosa compartments (1,307/1,404, 93%). Type I interferon signaling was the dominant signature of DEGs in HIV-positive blood with a less dominant and qualitatively distinct type I interferon gene set expression pattern in HIV-positive BAL. DEGs in the HIV-positive BAL were significantly enriched for infiltration with cytotoxic CD8+ T cells. Higher expression of representative transcripts and proteins in BAL CD8+ T cells during HIV infection, including IFNG (IFN-), GZMB (Granzyme B) and PDCD1 (PD-1), was confirmed by cell-subset specific transcriptional analysis and flow cytometry. Thus, we report that a whole transcriptomic approach revealed qualitatively distinct effects of HIV in blood and bronchoalveolar compartments. Further work exploring the impact of distinct type I interferon programs and CD8+ T cells infiltration of the lung mucosa during HIV infection may provide novel insights into HIV-induced susceptibility to respiratory pathogens.

2020-05-26 | GSE139327 | GEO

Characterization of the molecular interplay between Moraxella catarrhalis and human respiratory tract epithelial cells: Expression Moraxella catarrhalis strain BBH18 during adherence to human phanryngeal epithelial Detroit 562 cells

Project description:During the course of infection, respiratory pathogens like Moraxella catarrhalis needs to adhere to epithelial cells of different host niches such as the nasopharynx and lungs. Consequently, efficient adhesion to epithelial cells is considered an important virulence trait of M. catarrhalis. We examined the interaction between human pharyngeal epithelial Detroit 562 cells and M. catarrhalis BBH18 during adherence using a combination of Tn-seq, a genome-wide negative selection screenings technology, and expression profiling of both host and pathogen. The results described in this study are further discussed in Stefan P.W. de Vries, Marc J. Eleveld, Peter W.M. Hermans, Hester J. Bootsma: Characterization of the molecular interplay between Moraxella catarrhalis and human respiratory tract epithelial cells, submitted.

2013-06-27 | GSE47870 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data