Project description:We investigated microRNA expression profiles of gastric cancer tissues from Pdx-1-Cre;Cdh1F/+;Trp53F/F;Smad4F/F mice (pChePS_GC) and normal gastric epithelium (NGE) from Pdx1-1-Cre-negative mice. We used microarrays to detail the global microRNA expression underlying gastric carcinogenesis and identified distinct classes of up and down-regulated microRNAs during this process.
Project description:MicroRNA (miRNA) expression profiles for gastric cancers were examined to investigate the miRNA involvement in stomach carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate stomach cancers from noncancerous stomach tissues.
Project description:We investigated gene expression profiles of gastric cancer tissues from Pdx-1-Cre;Cdh1F/+;Trp53F/F;Smad4F/F mice (pChePS_GC), gastric cancer tissues from Pdx-1-Cre;Cdh1F/F;Trp53F/F mice (pCP_GC), and normal gastric epithelium (NGE) from Pdx1-1-Cre-negative mice. We used microarrays to detail the global programme of gene expression underlying gastric carcinogenesis and identified distinct classes of up and down-regulated genes during this process.