Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Assaying 6xIAPP toxicity

ABSTRACT: Assaying 6xIAPP toxicity

PROVIDER: PRJNA411917 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6062284.fastq.gz	Fastqsanger.gz
	SRR6062285.fastq.gz	Fastqsanger.gz
	SRR6062286.fastq.gz	Fastqsanger.gz
	SRR6062287.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Assaying 6xIAPP toxicity

Project description:Measuring the change in gene expression profiles in yeast in response to 6xIAPP expression in high toxicity conditions

2020-09-21 | GSE104172 | GEO

Assaying RNA Structure with LASER-seq

Project description:Assaying RNA Structure with LASER-seq

| PRJNA451460 | ENA

Assaying environmental nickel toxicity using model nematodes.

Project description:Although nickel exposure results in allergic reactions, respiratory conditions, and cancer in humans and rodents, the ramifications of excess nickel in the environment for animal and human health remain largely undescribed. Nickel and other cationic metals travel through waterways and bind to soils and sediments. To evaluate the potential toxic effects of nickel at environmental contaminant levels (8.9-7,600 µg Ni/g dry weight of sediment and 50-800 µg NiCl2/L of water), we conducted assays using two cosmopolitan nematodes, Caenorhabditis elegans and Pristionchus pacificus. We assayed the effects of both sediment-bound and aqueous nickel upon animal growth, developmental survival, lifespan, and fecundity. Uncontaminated sediments were collected from sites in the Midwestern United States and spiked with a range of nickel concentrations. We found that nickel-spiked sediment substantially impairs both survival from larval to adult stages and adult longevity in a concentration-dependent manner. Further, while aqueous nickel showed no adverse effects on either survivorship or longevity, we observed a significant decrease in fecundity, indicating that aqueous nickel could have a negative impact on nematode physiology. Intriguingly, C. elegans and P. pacificus exhibit similar, but not identical, responses to nickel exposure. Moreover, P. pacificus could be tested successfully in sediments inhospitable to C. elegans. Our results add to a growing body of literature documenting the impact of nickel on animal physiology, and suggest that environmental toxicological studies could gain an advantage by widening their repertoire of nematode species.

| S-EPMC3792034 | biostudies-literature

Benzene toxicity

Project description:Benzene toxicity

| PRJNA641636 | ENA

Assaying for RNA abundance and protein phosphorylation in pooled CRISPR screens

Project description:Assaying for RNA abundance and protein phosphorylation in pooled CRISPR screens

| PRJNA605978 | ENA

MMF toxicity

Project description:MMF toxicity Raw sequence reads

| PRJNA976489 | ENA

Faecalibacterium prausnitzii abrogates immunotherapy toxicity

Project description:Faecalibacterium prausnitzii abrogates immunotherapy toxicity

| PRJNA932844 | ENA

Rice-NaCl or Na2SO4 toxicity

Project description:Rice-NaCl or Na2SO4 toxicity

| PRJNA615618 | ENA

Renal Cyclosporin-A (CsA) toxicity

Project description:Renal Cyclosporin-A (CsA) toxicity

| PRJNA437288 | ENA

Synergistic Toxicity by Cadmium and Thiuram

Project description:Bioassay is a system for monitoring toxicity of chemicals in the environment via the biological responses of experimental organisms. These responses can be detected by analysis of genome-wide changes in mRNA expression levels using DNA microarray. We applied this system for evaluation of synergistic toxicity by cadmium and thiuram, as this combination showed mutual growth inhibition in yeast. Hierarchical cluster analysis using the mRNA expression profiles suggested the response of yeast to this combination is similar to that seen with cadmium treatment. Functional characterization of induced genes by this combination treatment also suggests the enhanced toxicity of cadmium. This toxicity was observed as the damage to mitochondrial functions which were not observed with either cadmium or thiuram treatments alone. The potential toxicity to mitochondria by this combinational treatment was confirmed as the result of mitochondrial curing. We could evaluate the synergistic toxicity by cadmium and thiuram and show the possible use of transcriptome bioassay for synergistic toxicity. Keywords: stress response

2007-09-01 | GSE8718 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data