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Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

ABSTRACT: Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

PROVIDER: PRJNA412535 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6116370.fastq.gz	Fastqsanger.gz
	SRR6116380.fastq.gz	Fastqsanger.gz
	SRR6116390.fastq.gz	Fastqsanger.gz
	SRR6116400.fastq.gz	Fastqsanger.gz
	SRR6116410.fastq.gz	Fastqsanger.gz

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Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

Project description:Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

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Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

Project description:Male breast cancer (MBC) is rare and poorly characterized. Like the female counterpart, most MBCs are hormonally driven, but resistance to hormonal treatment is common. The pan-hormonal action of steroid hormonal receptors including Estrogen Receptor alpha (ERα), Androgen Receptor (AR), Progesterone Receptor (PR) and Glucocorticoid Receptor (GR) in this understudied tumor type remains wholly unexamined. This pioneering study reveals genomic cross-talk of steroid hormone receptor action and interplay in human tumors, here in the context of MBC, in relation to patient outcome. Using chromatin immunoprecipitation coupled with massively-parallel sequencing (ChIP-seq), we characterized human MBCs for epigenetic make-up of hormonal regulation in human tumors, revealing genome-wide chromatin binding landscapes of ERα, AR, PR and GR, along with pioneer factor FOXA1 and enhancer-enriched histone mark H3K4me1. These data were integrated with transcriptomics analyses to reveal gender-selective and genomic location-specific hormone receptor action, that are associated with survival in MBC patients.

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Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer.

Project description:Male breast cancer (MBC) is rare and poorly characterized. Like the female counterpart, most MBCs are hormonally driven, but relapse after hormonal treatment is also noted. The pan-hormonal action of steroid hormonal receptors, including estrogen receptor alpha (ERα), androgen receptor (AR), progesterone receptor (PR), and glucocorticoid receptor (GR) in this understudied tumor type remains wholly unexamined. This study reveals genomic cross-talk of steroid hormone receptor action and interplay in human tumors, here in the context of MBC, in relation to the female disease and patient outcome. Here we report the characterization of human breast tumors of both genders for cistromic make-up of hormonal regulation in human tumors, revealing genome-wide chromatin binding landscapes of ERα, AR, PR, GR, FOXA1, and GATA3 and enhancer-enriched histone mark H3K4me1. We integrate these data with transcriptomics to reveal gender-selective and genomic location-specific hormone receptor actions, which associate with survival in MBC patients.

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