Project description:Expression profiling of 2555 miRNAs was performed using microarray. Of these, 451 miRNAs expressed in CCA cells. Microarray identified 17 miRNAs that were increased by > 1.5-fold and 56 miRNAs that were decreased by < 0.67-fold in CCA cells treated with TGF-β.
Project description:Cholangiocarcinoma (CCA) is a type of highly aggressive cancer arising from the biliary system. Through serum exosome miRNA sequencing, we screened out the differentially expressed miRNA in patients with cholangiocarcinoma(CCA) and common bile duct stones(CBDS).
Project description:Cholangiocarcinoma (CCA), consisting of three subtypes-intrahepatic (iCCA), perihilar (pCCA), and distal (dCCA), is a type of highly aggressive cancer arising from the biliary system and has an extremely poor prognosis. Through tissue miRNA sequencing, we screened out the differentially expressed miRNA in patients with 3 perihilar cholangiocarcinoma(pCCA) and 3 distal cholangiocarcinoma(dCCA) and its corresponding adjacent tissue.
Project description:Cholangiocarcinoma (CCA) is a type of highly aggressive cancer arising from the biliary system. Through miRNA sequencing, we screened that miR-182/183-5p was highly expressed in bile exosomes. miRNA affects gene expression by binding to mRNA or otehr. Here we profile the transcriptome of CCA cells following miR-182/183-5p overexpressing.
Project description:Cholangiocarcinoma (CCA) is a type of highly aggressive cancer arising from the biliary system. Through bile exosome miRNA sequencing, we screened out the differentially expressed miRNA in patients with perihilarl cholangiocarcinoma(pCCA) and common bile duct stones(CBDS).
Project description:Cholangiocarcinoma (CCA) is a type of highly aggressive cancer arising from the biliary system. Through bile exosome miRNA sequencing, we screened out the differentially expressed miRNA in patients with distal cholangiocarcinoma(dCCA) and common bile duct stones(CBDS).
Project description:We report the characterization of FOSL1-bound transcriptional targets in CCA cells. Target genes include different RNA species involving protein coding genes, lncRNA, miRNA and others