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Characterization of transcriptomics landscape in HUVEC cells exposed to oxidative stress

ABSTRACT: Characterization of transcriptomics landscape in HUVEC cells exposed to oxidative stress

OTHER RELATED OMICS DATASETS IN: GSE104666

PROVIDER: PRJNA413417 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6133850_1.fastq.gz	Fastqsanger.gz
	SRR6133850_2.fastq.gz	Fastqsanger.gz
	SRR6133860_1.fastq.gz	Fastqsanger.gz
	SRR6133860_2.fastq.gz	Fastqsanger.gz
	SRR6133851_1.fastq.gz	Fastqsanger.gz

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Characterization of transcriptomics landscape in HUVEC cells exposed to oxidative stress (Small RNA)

Project description:The aim of the project was to characterize the transcriptional landscape of human HUVEC cells exposed to oxidative stress (oxstress). In order to do so cell cultures have been exposed to 200uM H2O2 for either 16 hours or 36 hours to induce oxstress. Total ribodepleted RNA obtained from both time points have been sequenced and small RNA for the 16 hours time point have been sequenced as well. Datasets have been characterized and overlapped. This entry contains the dataset of small RNA.

2018-02-22 | GSE104663 | GEO

Characterization of transcriptomics landscape in HUVEC cells exposed to oxidative stress (Total RNA)

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Characterization of transcriptomics landscape in HUVEC cells exposed to oxidative stress (Small RNA)

Project description:Characterization of transcriptomics landscape in HUVEC cells exposed to oxidative stress (Small RNA)

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Characterization of transcriptomics landscape in HUVEC cells exposed to oxidative stress (Total RNA)

Project description:Characterization of transcriptomics landscape in HUVEC cells exposed to oxidative stress (Total RNA)

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Characterization of transcriptomics landscape in HUVEC cells exposed to oxidative stress

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-02-22 | GSE104666 | GEO

Regulation of oxidative stress in endothelial cells exposed to high glucose by selected microRNA

Project description:Hyperglycemia is the hallmark of diabetes mellitus that results in oxidative stress, endothelial dysfunction and vascular complications of diabetes. MicroRNAs (miRNAs) play a role in the development of endothelial dysfunction in diabetes, with potential application for the future therapy of diabetic vascular complications. However, there is a limited number of studies that characterize the miRNA profile of endothelial cells exposed to hyperglycemic condition. This study aimed to identify the miRNA profile of human umbilical vein endothelial cells (HUVEC) exposed to hyperglycemic state using RNA sequencing analysis.

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Project description:We sought to identify changes in gene expression that occur when endothelial cells (HUVEC) in monolayer interact with either uninfected or Listeria monocytogenes-infected macrophages. To that end we seeded HUVEC in monolayer and either exposed them to nothing, or to uninfected PMA-differentiated macrophage-like U937, or to Listeria monocytogenes-infected PMA-differenitated U937. At 8 hours post U937 exposure (hpe), cells were detached from the wells and cryopreserved for scRNA-seq. scRNa-seq analysis allowed us to distinguish endothelial cells from macrophage like cells and create appropirate clusters. By then analyzing the differentially expressed genes between all conditions for HUVEC and U937 separately, we identified a significant number of differentially regulated genes related to innate immune signaling in both infected U937 exposed HUVEC and to a lesser degree uninfected U937 exposed HUVEC, as compared to control unexposed HUVEC. By perofming pathway enrichment analysis, we also discovered that HUVEC exposed to uninfected U937 showed a higher upregulation in pathways related to mechanotransdcution, like "focal adhesions" and "regulation of the actin cytoskeleton", compared to those exposed to infected U937. This is consistent with the reinforsement of traction and monolayer stresses of HUVEC with uninfected U937 which we observe, a feature that is attenuated significanlty during infection. Finally, when we compare uninfected versus infected U937 cells from co-cultures, we find that the later upregulate cell adhesion molecules, the PI3K signaling pathway and focal adhesions, suggestive of increased cell contractility and adhesion as compared to uninfected U937.

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Project description:Proteomic and transcriptomic analysis of freshly isolated HUVEC and primary HUVEC on conventional plastic as well as bacterial-cellulose based support (Xellulin).

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