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Expression data from piperlongumine treated bladder cancer T24 cells

ABSTRACT: Expression data from piperlongumine treated bladder cancer T24 cells

PROVIDER: PRJNA413628 | ENA |

REPOSITORIES: ENA

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Expression data from piperlongumine treated bladder cancer T24 cells

Project description:Piperlongumine (PL), a natural alkaloid isolated from longer pepper plants, is recently found to be a potent selective anti-cancer compound. To further explore the therapeutic spectrum and molecular mechanisms of PL, we tested its anti-cancer effects in bladder cancer, the fifth most common and aggressive cancer worldwide. We used microarrays to detail the profile of miRNA expression underlying piperlongumine treatment and identified distinct classes of regulated microRNA during this process.

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Expression data from bladder cancer cells T24 treated with ox-LDL or vehicle

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Expression data from bladder cancer cells T24 - treated with G9a siRNA or negative control siRNA

Project description:Target genes regulated by G9a in bladder cancer cells T24 In this dataset, we include the expression data obtained from bladder cancer cells T24 treated with G9a siRNA or negative control siRNA. These data are used to obtain genes that are differentially expressed in response to G9a konckdown.

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Expression data for T24 bladder cancer cell line - scrambled, SOX4-KD and SOX4 overexpression

Project description:We knocked down SOX4 in T24 cell and created 3 cell lines: T24-scrambled, T24-SOX4-knockdown and T24-SOX4-rescue and compared gene expression changes SOX4 is a developmental transcription factor that is overexpressed in as many as 23% of bladder cancer patients, but the role of SOX4 in bladder cancer tumorigenesis is not well understood. Given SOX4’s many roles in embryonic development and context-dependent regulation of gene expression, we sought to understand SOX4’s contribution to bladder cancer and to elucidate SOX4 regulated genes that might contribute to tumorigenesis. We employed a CRISPR interference (CRISPRi) method to transcriptionally repress SOX4 expression in T24 bladder cancer cell lines, rescued these cell lines with lentivirally expressed SOX4, and performed whole genome expression profiling. SOX4 knockdown cells exhibited decreased invasive capabilities but no changes in migration or proliferation, while rescue with SOX4 lentiviral vector restored the invasive phenotype. Gene expression profiling revealed 173 high confidence SOX4 regulated genes

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Expression data from bladder cancer cells T24 treated with ox-LDL or vehicle

Project description:Expression data from bladder cancer cells T24 treated with ox-LDL or vehicle

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RNA-seq of miR-146a-5p overexpressing T24 human bladder cancer cells

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Project description:UBC9 knockdown in bladder cancer T24 cell lines

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