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B cell presentation of Chlamydia antigen selects out protective CD4ɣ13 T cells implications for genital tract tissue resident memory lymphocyte clusters

ABSTRACT: B cell presentation of Chlamydia antigen selects out protective CD4ɣ13 T cells implications for genital tract tissue resident memory lymphocyte clusters

PROVIDER: PRJNA413743 | ENA |

REPOSITORIES: ENA

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B cell presentation of Chlamydia antigen selects out protective CD4ɣ13 T cells; implications for genital tract tissue resident memory lymphocyte clusters

Project description:Surveillance and defense of the enormous mucosal interface with the nonsterile world is critical to protecting the host from a wide range of pathogens. Chlamydia trachomatis (Ct) is an intracellular bacterial pathogen that replicates almost exclusively in the epithelium of the reproductive tract. The fallopian tubes and vagina seem poorly suited to surveillance and defense as they have limited immune infrastructure positioned near the epithelium. However, a dynamic process during clearing primary infections leaves behind new immune infrastructure positioned near epithelium. Memory lymphocyte clusters (MLC) harboring tissue resident memory T cells (TRM) are presumed to play an important role in protection from subsequent infections. Histologically Chlamydia MLC appear to be based on B cells. We therefore investigated B cell populations in the murine genital tract post-clearance of C. muridarum infections and the nature of T cells recovered from immune mice using immune B cells as antigen presenting cells (APC). These studies revealed a plasma B cell population in the genital tract consistent with histopathology seen in mouse and human Chlamydia infections, and discovery of a novel CD4 T cell subset based on production of IFN-ɣ and IL-13. We discuss these results in the context of Trm and previously published data showing that in humans a peripheral blood mononuclear IL-13 response to elementary bodies (EB) predicts resistance to future infection.

2017-12-01 | GSE104743 | GEO

B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters.

Project description: Not available

| S-EPMC5778355 | biostudies-literature

Cannabinoids act as H3k27ac Epigenetic Modifiers of Genes Regulating MHC-I Antigen Processing and Presentation that Induce Cytolytic T Lymphocyte Recognition of Metastatic Cancers

Project description:Cannabinoids act as H3k27ac Epigenetic Modifiers of Genes Regulating MHC-I Antigen Processing and Presentation that Induce Cytolytic T Lymphocyte Recognition of Metastatic Cancers

2023-07-14 | GSE179897 | GEO

Gene expression profiling of oral and genital lichen planus epithelium and normal oral and genital epithelium

Project description:Comparing gene expression in Oral and genital lichen planus with normal oral and genital epithelium trying to idenitfy differently expressed genes in lichen planus compared to normal epithelium Total RNA obtained from oral and genital lichen planus epithelium compared with normal oral and genital epithelium

2013-11-08 | E-GEOD-52130 | biostudies-arrayexpress

Genital Tract Samples

Project description:Genital tract samples Raw

| PRJNA814891 | ENA

Gene expression profiling of oral and genital lichen planus epithelium and normal oral and genital epithelium

2013-11-08 | GSE52130 | GEO

IL-2 and IL-15 drive intrathymic differentiation of functionally distinct regulatory T lymphocyte-clusters

Project description:IL-2 and IL-15 drive intrathymic differentiation of functionally distinct regulatory T lymphocyte-clusters

| PRJNA645186 | ENA

Baseline gene transcription in genital fibroblasts

Project description:To gain insights into the role of androgen in genital morphogenesis, we compared basal transcriptional patterns in genital fibroblasts from 46,XY individuals with either wild-type AR or germline inactivation of the AR as a result of mutation. A disease state experiment design type is where the state of some disease such as infection, pathology, syndrome, etc is studied. Keywords: disease_state_design

2005-12-21 | GSE3872 | GEO

Baseline gene transcription in genital fibroblasts

2005-12-20 | E-GEOD-3872 | biostudies-arrayexpress

Genital fibroblasts of normal males and 46,XY females with androgen insensitivity syndrome

Project description:Abstract: BACKGROUND: Androgen insensitivity syndrome (AIS) comprises a range of phenotypes from male infertility to complete feminization. Most individuals with AIS carry germline mutations of the androgen receptor (AR) that interfere with or ablate its function. As genital fibroblasts retain expression of the AR in vitro, we used genital skin fibroblasts from normal males and 46,XY females with complete AIS due to known AR mutations to gain insights into the role of the AR in human genital differentiation. RESULTS: Using DNA microarrays representing 32,968 different genes, we identified 404 transcripts with significant differences in transcription levels between genital skin fibroblasts cultured from normal and AIS-affected individuals. Gene-cluster analyses uncovered coordinated expression of genes involved in key processes of morphogenesis. On the basis of animal studies and human genetic syndromes, several of these genes are known to have specific roles in genital differentiation. Remarkably, genital fibroblasts from both normal and AIS-affected individuals showed no transcriptional response to dihydrotestosterone treatment despite expression of the AR. CONCLUSIONS: The results suggest that in addition to differences in the anatomic origin of the cells, androgen signaling during prenatal development contributes to setting long-lasting, androgen-independent transcriptional programs in genital fibroblasts. Our findings have broad implications in understanding the establishment and the stability of sexual dimorphism in human genital development. This SuperSeries is composed of the SubSeries listed below.

2006-03-07 | GSE4353 | GEO

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