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Glomerular Transcriptome from European Renal cDNA Bank subjects and living donors

ABSTRACT: Glomerular Transcriptome from European Renal cDNA Bank subjects and living donors

OTHER RELATED OMICS DATASETS IN: GSE108113

PROVIDER: PRJNA414218 | ENA |

REPOSITORIES: ENA

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Glomerular Transcriptome from European Renal cDNA Bank subjects and living donors

Project description:summary : Glomerular Transcriptome from European Renal cDNA Bank subjects and living donors. Samples included in this analysis have been previously analyzed using older CDF definitions and are included under previous GEO submissions - GSE47183 (chronic kidney disease samples), and GSE32591 (IgA nephropathy samples).

2018-01-24 | GSE104948 | GEO

Glomerular Transcriptome from European Renal cDNA Bank subjects and living donors

Project description:Glomerular Transcriptome from European Renal cDNA Bank subjects and living donors. Samples included in this analysis have been previously analyzed using older CDF definitions and are included under previous GEO submissions - GSE47183 (chronic kidney disease samples), and GSE32591 (IgA nephropathy samples). RNA from the glomerular compartment of was extracted and processed for hybridization on Affymetrix microarrays, annotated using Human Entrez Gene ID custom CDF version 19. This dataset is part of the TransQST collection.

2018-01-24 | E-GEOD-104948 | biostudies-arrayexpress

Glomerular RNAseq counts from the Neptune Cohort and healthy living donors

Project description:Glomerular Transcriptome in the Neptune Cohort

2022-04-13 | GSE197307 | GEO

Glomerular voom-transformed RNAseq counts from the Neptune Cohort and healthy living donors [re-analysis of GSE197307]

Project description:Glomerular Transcriptome in the Nephrotic Syndrome study network cohort

2024-02-07 | GSE254957 | GEO

Universal stool bank donors

Project description:16S rRNA sequencing of samples from universal stool bank donors

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Glomerular transcriptome from subjects in the NEPTUNE cohort

Project description:Glomerular Transcriptome from subjects in the NEPTUNE cohort. A number of samples profiled in this analysis were also profiled in Series GSE68127, and Series GSE108113. RNA from the glomerular compartment of was extracted and processed for hybridization on Affymetrix microarrays. Contributor: NEPTUNE Consortium. This dataset is part of the TransQST collection.

2018-05-17 | E-GEOD-104066 | biostudies-arrayexpress

Glomerular RNAseq counts from the Neptune Cohort and healthy living donors

Project description:Glomerular RNAseq counts from the Neptune Cohort and healthy living donors

| PRJNA809711 | ENA

Glomerular Transcriptome from subjects in the NEPTUNE cohort

Project description:Glomerular Transcriptome from subjects in the NEPTUNE cohort. A number of samples profiled in this analysis were also profiled in Series GSE68127, and Series GSE108113.

2018-05-17 | GSE104066 | GEO

Longitudinal Trajectories of Estimated Glomerular Filtration Rate in a European Population of Living Kidney Donors.

Project description:A living donor (LD) kidney transplant is the best treatment for kidney failure, but LDs safety is paramount. We sought to evaluate our LDs cohort's longitudinal changes in estimated glomerular filtration rate (eGFR). We retrospectively studied 320 LDs submitted to nephrectomy between 1998 and 2020. The primary outcome was the eGFR change until 15 years (y) post-donation. Subgroup analysis considered distinct donor characteristics and kidney function reduction rate (%KFRR) post-donation [-(eGFR6 months(M)-eGFRpre-donation)/eGFRpre-donation*100]. Donors had a mean age of 47.3 ± 10.5 years, 71% female. Overall, LDs presented an average eGFR change 6 M onward of +0.35 mL/min/1.73 m2/year. The period with the highest increase was 6 M-2 Y, with a mean eGFR change of +0.85L/min/1.73 m2/year. Recovery plateaued at 10 years. Normal weight donors presented significantly better recovery of eGFR +0.59 mL/min/1.73 m2/year, compared to obese donors -0.18L/min/1.73 m2/year (p = 0.020). Noteworthy, these results only hold for the first 5 years. The subgroup with a lower KFRR (<26.2%) had a significantly higher decrease in eGFR overall of -0.21 mL/min/1.73 m2/year compared to the groups with higher KFRR (p < 0.001). These differences only hold for 6 M-2 Y. Moreover, an eGFR<50 mL/min/1.73 m2 was a rare event, with ≤5% prevalence in the 2-15 Y span, correlating with eGFR pre-donation. Our data show that eGFR recovery is significant and may last until 10 years post-donation. However, some subgroups presented more ominous kidney function trajectories.

| S-EPMC11381247 | biostudies-literature

Single glomerular podocyte RNA-seq analysis

Project description:Available single-cell RNA-seq analyses have revealed that individual cells of the same type differ substantially in gene expression. We wonder whether glomerular podocytes, the cell type that is part of glomerular filtration, also exhibit big difference in gene expression among individual cells; and what biological information could be obtained from the single-podocyte RNA-seq data. Therefore, we isolated mouse glomeruli by Dynabead/magnetic concentration method, and digested them with enzymes to dissociate the cells. We loaded the single cell suspension to a Fluidigm C1 Single-Cell Auto Prep System for single cell cDNA preparation. The cDNA samples were amplified and underwent sequecing using Illumina Highseq 2000 system.

2017-07-31 | GSE88814 | GEO

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