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Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo (lungs)

ABSTRACT: Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo (lungs)

PROVIDER: PRJNA414568 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6180300_1.fastq.gz	Fastqsanger.gz
	SRR6180300_2.fastq.gz	Fastqsanger.gz
	SRR6180301_1.fastq.gz	Fastqsanger.gz
	SRR6180301_2.fastq.gz	Fastqsanger.gz
	SRR6180302_1.fastq.gz	Fastqsanger.gz

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Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo (lungs and spleens)

Project description:Here we compare gene expression profiles between lungs and spleens following LPS in vivo injection into Wild type, lincRNA-Cox2 knockout and lincRNA-Cox2 mutant mice The aim of the experiment is to determine the cis and trans functions for lincRNA-Cox2 following in vivo LPS challenge within the spleen and lung

2018-12-19 | GSE116354 | GEO

Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo (lungs)

Project description:Here we compare gene expression profiles between lungs taken from a Wild type mouse to lungs from a lincRNA-Cox2 knockout mouse The aim of the experiment is to determine what impact lincRNA-Cox2 has on gene expression within the lung

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Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo (lungs and spleens)

Project description:Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo (lungs and spleens)

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Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo

Project description:Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo

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Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo (macrophages)

Project description:Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo (macrophages)

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Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.

Project description:An inducible gene expression program is a hallmark of the host inflammatory response. Recently, long intergenic non-coding RNAs (lincRNAs) have been shown to regulate the magnitude, duration, and resolution of these responses. Among these is lincRNA-Cox2, a dynamically regulated gene that broadly controls immune gene expression. To evaluate the in vivo functions of this lincRNA, we characterized multiple models of lincRNA-Cox2-deficient mice. LincRNA-Cox2-deficient macrophages and murine tissues had altered expression of inflammatory genes. Transcriptomic studies from various tissues revealed that deletion of the lincRNA-Cox2 locus also strongly impaired the basal and inducible expression of the neighboring gene prostaglandin-endoperoxide synthase (Ptgs2), encoding cyclooxygenase-2, a key enzyme in the prostaglandin biosynthesis pathway. By utilizing different genetic manipulations in vitro and in vivo, we found that lincRNA-Cox2 functions through an enhancer RNA mechanism to regulate Ptgs2. More importantly, lincRNA-Cox2 also functions in trans, independently of Ptgs2, to regulate critical innate immune genes in vivo.

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Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-12-19 | GSE117379 | GEO

Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2 in vivo (macrophages)

Project description:Here we amplified a region in exon 5 of Ptgs2 that contains SNPs to allow us to differenitate between the C57 allele and the MOLF allele

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Trans-chromosomal regulation by a novel lincRNA required for adipogenesis that escapes X-chromosome inactivation

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Trans-chromosomal regulation by a novel lincRNA required for adipogenesis that escapes X-chromosome inactivation

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